郭 崢

華中科技大學(xué)

同濟醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院醫(yī)學(xué)遺傳學(xué)系

• 基礎(chǔ)醫(yī)學(xué)院教授，博導(dǎo)

• 醫(yī)學(xué)遺傳系，主任

• 實驗室網(wǎng)頁：http://www.guozhenglab.net

聯(lián)系地址：

湖北省武漢市硚口區(qū)航空路13號同濟醫(yī)學(xué)院形態(tài)學(xué)樓102室

聯(lián)系方式：

電話:  86(27) 13545037970

郵箱:  guozheng@hust.edu.cn

教育與工作經(jīng)歷：

2016-至今, 教授、醫(yī)學(xué)遺傳學(xué)系系主任 華中科技大學(xué)同濟醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院2011-2016, 博士后，美國哥倫比亞大學(xué)醫(yī)學(xué)院遺傳與發(fā)育生物學(xué)系。

2004-2011, 中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所，發(fā)育生物學(xué)博士學(xué)位

實驗室研究領(lǐng)域及內(nèi)容:

目前實驗室利用果蠅與小鼠為模式動物，對腸道干細胞的多功能分化進行深入研究，以期理解干細胞分化的內(nèi)在生理邏輯和分子基礎(chǔ)，以達到對癌癥以分化為導(dǎo)向的轉(zhuǎn)化醫(yī)學(xué)治療。主要研究內(nèi)容為：1）腸道表皮干細胞數(shù)目的決定機制；2）腸道表皮干細胞位置的決定機制；3）腸道干細胞分化過程中Notch信號激活強弱的控制機制；4)腸道干細胞多功能分化的子代細胞比例控制機制。文章發(fā)表在Science, Developmental Cell, PNAS, Nature Communications, Science Advances, Cell Reports, Development等國際著名雜志。

研究論文：

1. Wu, Y., Yu, L., Yu, Y., Wu, S., Yuan, Q., Duan, W., Cai, S., Xiong, B., Lin, R., and Guo, Z. (2025). Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation. Sci Adv 11, eady7272. 10.1126/sciadv.ady7272.

2. Qin, P., Wang, Q., Wu, Y., You, Q., Li, M., and Guo, Z. (2025). Age mosaic of gut epithelial cells prevents aging. Nature communications 16, 6734. 10.1038/s41467-025-62043-y.

3. Li, A., Tong, D., Ohlstein, B., and Guo, Z. (2025). Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 122, e2513015122. 10.1073/pnas.2513015122.

4. Zhang, S., Wu, S., Yao, R.N., Wei, X.Y., Ohlstein, B., and Guo, Z. (2024). Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila. Developmental cell 59. 10.1016/j.devcel.2023.11.016.

5. Gao, J., Zhang, S., Deng, P., Wu, Z., Lemaitre, B., Zhai, Z., and Guo, Z. (2024). Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. Nature communications 15, 3514. 10.1038/s41467-024-47465-4.

6. Wu, S., Yang, Y., Tang, R., Zhang, S., Qin, P., Lin, R., Rafel, N., Lucchetta, E.M., Ohlstein, B., and Guo, Z. (2023). Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. Cell reports 42, 112093. https://doi.org/10.1016/j.celrep.2023.112093.

7. Wu, S., Tang, R., Ohlstein, B., and Guo, Z. (2023). A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut. STAR protocols 4, 102749. 10.1016/j.xpro.2023.102749.

8. Tang, R., Qin, P., Liu, X., Wu, S., Yao, R., Cai, G., Gao, J., Wu, Y., and Guo, Z. (2021). Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Communications biology 4, 1223. 10.1038/s42003-021-02757-z.

9. Guo, Z., Lucchetta, E., Rafel, N., and Ohlstein, B. (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development 40, 81-86. 10.1016/j.gde.2016.06.009.

10. Guo, Z., and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science 350. 10.1126/science.aab0988.

11. Guo, Z., Driver, I., and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. The Journal of cell biology 201, 945-961. 10.1083/jcb.201302049.

12. Guo, Z., and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development 136, 3627-3635. 10.1242/dev.036939.

獲得榮譽：

第十三批中組部“千人計劃”青年項目。

獲得資助:

自然科學(xué)基金委面上項目四項，實驗室博士后獲得自然科學(xué)基金委青年基金一項，國家博士后基金一項。

教授課程：

1001101 細胞生物學(xué)Cell Biology (本科)

1001121 醫(yī)學(xué)遺傳學(xué)Medical Genetics (本科、碩士)

510.543 醫(yī)學(xué)遺傳學(xué)進展Advances in Medical Genetics (碩士)

510.805 醫(yī)學(xué)遺傳學(xué)進展Advanced Medical Genetics (博士)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (博士)

在研課題：

1. Determine the mechanism of the “differentiation toggle” in Drosophila ISCs.

2. Determine the mechanism of high-low Notch signaling establishment.

3. To determine whether mammalian intestinal stem cells use the same bidirectional Notch signaling to regulate multipotency.