陳偉，教授，博士生導(dǎo)師，國家海外高層次青年人才（2022），湖北省“杰青”（2022），湖北省“百人計劃”（2021）入選者。陳教授2009年于武漢大學(xué)化學(xué)基地班專業(yè)獲理學(xué)學(xué)士學(xué)位，2014年在浙江大學(xué)化學(xué)系獲得博士學(xué)位。2015-2018年在美國國立衛(wèi)生研究院National Institutes of Health（NIH）陳小元教授課題組從事博士后研究，2018-2020年于麻省理工學(xué)院（Massachusetts Institute of Technology, MIT）Robert S. Langer教授（美國三院院士，2021年增選為中國工程院外籍院士）課題組任研究科學(xué)家（Research Scientist）。2021年加入華中科技大學(xué)同濟醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院藥理學(xué)系，任教授，兼任Chinese Chemical Letters和MedComm – Biomaterials and Application青年編委，以及Journal of Nanobiotechnology客座編輯。擔(dān)任湖北省藥理學(xué)會第十屆理事會理事，以及湖北省藥理學(xué)會黨支部青年委員和宣傳委員。
研究方向：智能器件，智控藥劑，手術(shù)輔助系統(tǒng)，診療增強系統(tǒng)，交叉轉(zhuǎn)化系統(tǒng)
聯(lián)系方式：weichen86@hust.edu.cn/weichensci@hotmail.com,歡迎材料，化學(xué)，生物，醫(yī)學(xué)，工程等相關(guān)專業(yè)學(xué)生報考。
英文主頁：WeiChen_WorldChanging Group
ORCID:0000-0003-3611-2760
陳教授長期從事利用生物啟發(fā)技術(shù)構(gòu)建智控藥劑及智能器件用于疾病診斷治療的研究。圍繞增強藥物療效、提升病人依從性以及增加生物樣本采樣準(zhǔn)確性等關(guān)鍵臨床問題，陳教授基于自身的研究背景，學(xué)習(xí)并借鑒自然界中存在生物原理，發(fā)展了系列生物啟發(fā)智能系統(tǒng)：（1）模擬生物硬組織形成，制備仿生礦化藥物制劑，逆轉(zhuǎn)了腫瘤耐藥性；（2）模擬生物自發(fā)驅(qū)動，開發(fā)了生物表面修飾及改性技術(shù)，調(diào)控生物體定向遷移特性；（3）模擬多刺生物防御，成功構(gòu)建了血糖響應(yīng)型微針貼片，便利、長效調(diào)控病人血糖；（4）模擬刺頭蠕蟲寄生，創(chuàng)造超強生物粘附微針?biāo)幤瑢崿F(xiàn)了大分子藥物高效口服遞送；（5）模擬鳥類舌尖采集食品，發(fā)展可富集病毒微針咽拭子提高了流行病病原體檢測準(zhǔn)確性；（6）模擬海洋生物附著，制作了定向牽引抗菌微針創(chuàng)可貼，高效修復(fù)感染性全層皮膚缺損；（7）模擬豬籠草液體引流，發(fā)明了智能牙套裝置，實現(xiàn)口腔癌早期預(yù)警。第一及通訊作者已發(fā)表SCI論文40余篇，包括Sci. Adv. (2025), ACS Nano (2025),Adv. Sci. (2024),Chem. Eng. J. (2024), Small (2024), Device (2023), Adv. Drug Deliv. Rev. (2023), ACS Nano (2023), Adv. Sci. (2023), J. Control. Release (2023) Sci. Adv. (2022), Nano Lett. (2022), Adv. Mater. (2022), ACS Nano (2022), J. Nanobiotechnology (2022), Theranostics (2021)，Matter (2020), Nano today (2020), Nano Lett. (2019), Adv. Drug Deliv. Rev. (2018), Nat. Commun. (2017), ACS nano (2017), Small (2014,2015), J. Control. Release (2015)等，其中影響因子大于11的論文30余篇，10項專利已獲授權(quán)。以重要骨干身份參與了美國國立衛(wèi)生研究院研究計劃，以及麻省理工學(xué)院-諾和諾德聯(lián)合研究項目，成果被NIH和MIT重點推薦，并被Cell出版社以及多家媒體相繼轉(zhuǎn)載。相關(guān)工作榮獲首批湖北省實驗室亮點科技成果，指導(dǎo)學(xué)生獲第十八及十九屆“挑戰(zhàn)杯”全國主賽道全國一等獎、首批國家自然科學(xué)基金青年學(xué)生基礎(chǔ)研究項目（博士研究生項）及首屆中國科協(xié)青年人才托舉工程博士生專項。陳教授工作已展現(xiàn)出較高的商業(yè)及臨床轉(zhuǎn)化潛力，相關(guān)工作已進入臨床試驗階段。
部分代表性工作概覽
近期新聞：
Sci Adv |植入式藥物遞送系統(tǒng)，實現(xiàn)42天藥物精準(zhǔn)遞送，慢病長治
再創(chuàng)佳績！基礎(chǔ)醫(yī)學(xué)院再奪“挑戰(zhàn)杯”國賽一等獎！
華中科技大學(xué)王琳、陳偉、王征《Nano Letters》：仿螳螂前肢的生物可吸收隱形眼鏡狀裝置（BLOT）治療細菌性角膜炎
新文快訊】ACS Nano Med.搭載弓形蟲衍生抗原的仿蒼耳結(jié)構(gòu)植入體用于長效免疫治療乳腺癌
突破IBD治療瓶頸：精準(zhǔn)給藥新范式如何改寫治療格局？MedComm-Biomater Appl.
自供能藻類集成可穿戴供氧系統(tǒng)用于缺氧性疾病治療（ACSNano）
基礎(chǔ)醫(yī)學(xué)院在首屆全國研究生學(xué)術(shù)創(chuàng)新與成果轉(zhuǎn)化大賽中斬獲佳績
華科大基礎(chǔ)醫(yī)學(xué)院藥理學(xué)系陳偉教授團隊研究成果Small：“內(nèi)外協(xié)同”工程化腸吻合策略實現(xiàn)腸瘺智能管理
華科大基礎(chǔ)醫(yī)學(xué)院陳偉教授團隊最新研究成果CEJ：受豬籠草啟發(fā)的“SALAD”護齒器用于口腔癌早期預(yù)警
基礎(chǔ)醫(yī)學(xué)院榮獲第十七屆全國大學(xué)生創(chuàng)新年會優(yōu)秀學(xué)術(shù)論文獎
恭喜陳偉教授課題組陳秀麗同學(xué)榮獲華中科技大學(xué)本科生自然科學(xué)創(chuàng)新基金項目資助
基礎(chǔ)醫(yī)學(xué)院陳偉教授團隊博士生龔宇晟獲首批國家自然科學(xué)基金青年學(xué)生基礎(chǔ)研究項目（博士研究生）資助
基礎(chǔ)醫(yī)學(xué)院在“挑戰(zhàn)杯”全國決賽主體賽中榮獲一等獎
華中科技大學(xué)同濟醫(yī)學(xué)院陳偉教授ADDR：超聲可觸發(fā)/皮膚相關(guān)的微型器件用于智能藥物遞送與醫(yī)學(xué)診斷
專訪華科大陳偉丨高科技、低成本，攪拌磁子化身「磁性機器人」，解決臨床腸道疾病精準(zhǔn)靶向治療難題
華中科大-陳偉&NUS-陳小元︱受小腸絨毛啟發(fā)的數(shù)學(xué)工程化底紋貼片用于各類粘膜高效生物標(biāo)志物富集與藥物快速沉積
Chemical Engineering Journal基礎(chǔ)醫(yī)學(xué)院陳偉教授團隊最新成果：基于光降解的鐵交聯(lián)海藻酸鈉微針貼片用于干燥病治療
受自加熱食品啟發(fā)，華科陳偉教授團隊研發(fā)可觸發(fā)微針系統(tǒng)，實現(xiàn)高效局部藥物遞送
華科大本科生團隊一項科研成果顯示變蟲為寶——“滅活血吸蟲蟲卵”或可輔助治療1型糖尿病
Adv Sci綜述︱華中大陳偉團隊評述時空精準(zhǔn)技術(shù)實現(xiàn)神經(jīng)系統(tǒng)疾病的按需干預(yù)
華中大陳偉/王婷團隊《J. Nanobiotechnol.》：尖端搭載無佐劑日本血吸蟲蟲卵的不對稱微針貼片治療1型糖尿病
陳小元/王琳/王征/陳偉ACS Nano:微針圖案，用于疫苗接種
華中大陳偉教授、麻省理工Traverso教授等《Sci. Adv.》：生物大分子的口服遞送策略-動態(tài)全向粘附微針陣列系統(tǒng)
感染性皮膚傷口的修復(fù)|華中科技大學(xué)王琳/王征/陳偉教授團隊《Nano Letters》：仿生定向牽引抗菌絲膠微針高效修復(fù)感染性全層皮膚缺損
華中科技大學(xué)基礎(chǔ)醫(yī)學(xué)院陳偉教授等在Theranostics綜述搭載活性物質(zhì)的智能微針系統(tǒng)在生物醫(yī)學(xué)中應(yīng)用
陳偉教授團隊《Advanced Materials》綜述未來科技改變生活：輕便小型智能可穿戴器件的創(chuàng)新與發(fā)展
華中科技大重磅成果！自發(fā)富集病毒微針拭子，減少新冠檢測的“假陰性”！
可自發(fā)調(diào)節(jié)的糖尿病治療貼片美國國立衛(wèi)生研究院陳小元團隊陳偉博士《Nature Communications》
代表性論文：
1.Zeng, Qi; Gong, Yusheng; Jiao, Wenhao; Xu, Jiarong; Chen, Xiuli; Xu, Rengui; Liu, Yuan; Liang, Xinting; Li, Guanyue; Liu, Jiajing; He, Linxi; Li, Wenhao; Zhang, Xiaoxia; Chen, Xiaoyuan*; Chen, Wei*, Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy,Sci Adv2025,11(26), eadv8734.
2.Xu, Jiarong; Chen, Xiuli; Wu, Junhai; Cui, Yuying; Wang, Pengyuan; Li, Yufeng; Li, Jiamin; Zeng, Qi; Xu, Rengui; Gong, Yusheng; Liu, Yuan; Li, Guanyue; He, Linxi; Liu, Jiajing; Jiao, Wenhao; Liang, Xinting; Zeng, Feiyang; Zheng, Qihan; Ye, Nanxin; Cui, Qi; Fang, Zhengming; Wang, Ting; Chen, Wei, Cocklebur-inspired implantable and anchored device for lasting tumor immunotherapy based on soluble toxoplasma gondii antigen,ACS Nano Medicine2025, DOI: 10.1021/acsnanomed.5c00034.
3.Liang, Xinting#; Yang, Lei#; Chen, Xiuli#; Gong, Yusheng; Xu, Rengui; Zeng, Qi; Xu, Jiarong; Liu, Jiajing; Liu, Yuan; Li, Guanyue; He, Linxi; Jiao, Wenhao; Liu, Hui*; Chen, Wei*, Swift-acting structured lattice-enhanced caramelized sucrose system for painless sedative delivery,Biomaterials2025, 10.1016/j.biomaterials.2025.123823.
4.Li, Guanyue; He, Linxi; Xu, Jiarong; Gong, Yusheng; Zeng, Qi; Chen, Xiuli; Jiao, Wenhao; Liu, Yuan; Liu, Jiajing; Xu, Rengui; Liang, Xinting; Chen, Wei*, Self-powered algae-integrated wearable system for oxygen supplementation in hypoxic disease treatment,ACS Nano2025,19(17), 16940-16956.
5.Gan, Ruoyi; Ni, Enqi; Li, Guanyue; Chen, Wei*, A new paradigm for precision drug delivery in inflammatory bowel disease: effective transfer, enhanced retention, and pathology‐targeting treatment via biomaterials and engineered platforms,MedComm–Biomaterials and Applications2025,4, e70022.
6.Deng, Yan#; Xu, Rengui#; Chen, Fenghua#; Zhang, Lifang; Wei, Chunyu; Guo, Honglian; Wang, Zheng*; Chen, Wei*; Wang, Lin*, Engineering of a Mantis-Forelimb-Inspired Bioabsorbable Lens-like Ocular Therapeutic (BLOT) Device for Effective Bacterial Keratitis Treatment,Nano Lett.2025, 10.1021/acs.nanolett.5c03995.
7.Liu, Yuan; Chen, Xiuli; Li, Guanyue; Xu, Jiarong; Zeng, Qi; Xu, Rengui; Gong, Yusheng; Chen, Wei*, Nepenthes-inspired saliva-amassing low-dosed risk-factor alerted detecting (SALAD) mouthguard for forewarning of the intraoral cancer,Chem. Eng. J.2024,502, 157802.
8.Li, Qilin#; Wei, Chunyu#; Xu, Luming; Zhang, Jiao; Li, Yuyu; Lu, Xiaohuan; Xu, Rengui; Guo, Honglian; Cao, Peng; Ouyang, Chenke; Xu, Jiarong; Chen, Wei*; Wang, Zheng*; Wang, Lin*, A smart semi-implantable device integrating microchannel-enhanced sampling and multiplex biochemical testing for deep wound monitoring and pathogen identification,Adv. Sci.2024, 2407868.
9.Chen, Xiuli; Gong, Yusheng; Li, Min; Zeng, Qi; Xu, Rengui; Li, Xiaodong; Lu, Xiang; Song, Shang; Xu, Jiarong; Li, Guanyue; Yang, Jingwen; Jiao, Wenhao; Liu, Jiajing; Liu, Yuan; Liang, Xinting; He, Linxi; Xiao, Fei; Chen, Wei*, An interior/exterior collaboration-enhanced intestinal anastomosis (IECIA) for multi-tiered leakage complication management,Small2024, 2408222.
10.Zeng, Qi#; Li, Guanyue#; Chen, Wei*, Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis,Adv. Drug Deliv. Rev.2023, 115133.
11.Gong, Yusheng; Tong, Shuai; Li, Xixuan; Chen, Xiuli; Liu, Yushuang; Li, Nan; Xu, Jiarong; Xu, Rengui; Guo, Yusong; Xiao, Fei; Chen, Xiaoyuan*; Chen, Wei*, Intestinal villi-inspired mathematically base-layer engineered microneedles (IMBEMs) for effective molecular exchange during biomarker enrichment and drug deposition in diversified mucosa,ACS Nano2023,7, 15696-15712.
12.Xu, Jiarong; Zeng, Qi; Chen, Xiuli; Guo, Honglian; Gong, Yusheng; Xu, Rengui; Cao, Peng; Wei, Chunyu; Xiao, Fei; Jiang, Dawei*; Chen, Wei*, Iron (III) cross-linked alginate microneedle patch for xerosis treatment based on controllable photodegradation,Chem. Eng. J.2023, 145672.
13.Chen, Xiuli; Gong, Yusheng; Chen, Wei.*, Advanced temporally-spatially precise technologies for on-demand neurological disorder intervention,Adv. Sci.2023,10(14), e2207436.
14.Wang, Zheng#*; Li, Qilin#; Cao, Peng#; Zhang, Jiao; Wu, Di; Xu, Rengui; Zhang, Yan; Xu, Yunruo; Liang, Tao; Chen, Wei*; Wang, Lin*; Chen, Xiaoyuan*, A biomimetic helical robot actuated by rotating magnetic field for targeted navigation and in situ prodrug activation to treat intestinal diseases,Device2023,1, 10064.
15.Xu, Rengui; Guo, Honglian; Chen, Xiuli; Xu, Jiarong; Gong, Yusheng; Cao, Peng; Wei, Chunyu; Xiao, Fei; Wu, Di; Chen, Wei*; Wang, Lin*; Wang, Zheng*, Smart hydrothermally responsive microneedle for topical tumor treatment,J. Control. Release2023,358, 566-578.
16.Dai, Jun#; Wei, Siming#; Xu, Jiarong#; Xue, Huiying; Chen, Zhaojun; Wu, Meng; Chen, Wei*; Lou, Xiaoding; Xia, Fan*; Wang, Shixuan*, Microneedle device delivering aggregation-induced emission photosensitizers for enhanced metronomic photodynamic therapy of cancer,ACS Appl. Mater. Interfaces2023,15, 16526–16538.
17.Yu, Yajie#; Lv, Bing#; Wu, Juntao; Chen, Wei*, Mussel-based biomimetic strategies in musculoskeletal disorder treatment: from synthesis principles to diverse applications,Int. J. Nanomedicine2023,18, 455-472.
18.Liu, Yuan; Huang, Ting; Qian, Zhiyong*; Chen, Wei*, Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment,Chin. Chem. Lett.2023, 108103.
19.Chen, Wei; Wainer, Jacob; Ryoo, Si Won; Qi, Xiaoyue; Chang, Rrong; Li, Jason; Lee, Seung Ho; Min, Seokkee; Wentworth, Adam; Collins, Joy; Tamang, Siddartha; Ishida, Keiko; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery,Sci. Adv.2022,8, eabk1792.
20.Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart chemical engineering‐based lightweight and miniaturized attachable systems for advanced drug delivery and diagnostics,Adv. Mater.2022,34(6), 2106701.
21.Huang, Haoming#; Hu, Dian#; Chen, Zhuo#; Xu, Jiarong; Xu, Rengui; Gong, Yusheng; Fang, Zhengming; Wang, Ting*; Chen, Wei*, Immunotherapy for type 1 diabetes mellitus by adjuvant-free Schistosoma japonicum-egg tip-loaded asymmetric microneedle patch (STAMP),J. Nanobiotechnology2022,20(1), 377.
22.Li, Qilin#; Xu, Rengui#; Fan, Huiling#; Xu, Jiarong; Xu, Yunruo; Cao, Peng; Zhang, Yan; Liang, Tao; Zhang, Yang; Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage,ACS Nano2022,16(5), 7512-7524.
23.Deng, Yan#; Yang, Cheng#; Zhu, Yuanyuan; Liu, Wenyu; Li, Heli; Wang, Liping; Chen, Wei*; Wang, Zheng*; Wang, Lin*, Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement,Nano Lett.2022,22(7), 2702-2711.
24.Liu, Yuan; Guo, Honglian; Xu, Rengui; Chen, Wei*, Smart intraoral systems for advanced drug delivery,MedComm – Biomaterials and Applications2022,1, e19.
25.Cai, Bo#; Gong, Yusheng#; Wang, Zheng*; Wang, Lin*; Chen, Wei*, Microneedle arrays integrated with living organisms for smart biomedical applications,Theranostics2021,11(20), 10012-10029.
26.Chen, Wei#; Huang, Ting#; Shi, Kun; Chu, Bingyang; Qian, Zhiyong*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement,Nano Today2020,35, 100966.
27.Chen, Wei*; Cai, Bo; Geng, Zhi; Chen, Fenghua; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs,Matter2020,3(5), 1589-1600.
28.Chen, Wei; Shi, Kun; Chu, Bingyang; Wei, Xiawei*; Qian, Zhiyong*, Mitochondrial surface engineering for multidrug resistance reversal,Nano Lett.2019,19(5), 2905-2913.
29.Chen, Wei; Yung, Bryant C; Qian, Zhiyong*; Chen, Xiaoyuan*, Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction,Adv. Drug Deliv. Rev.2018,127, 20-34.
30.Chen, Wei; Tian, Rui; Xu, Can; Yung, Bryant C.; Wang, Guohao; Liu, Yijing; Ni, Qianqian; Zhang, Fuwu; Zhou, Zijian; Wang, Jingjing; Niu, Gang; Ma, Ying; Fu, Liwu*; Chen, Xiaoyuan*, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy,Nat. Commun.2017, 1777.
31.Chen, Wei; Wang, Guohao; Yung, Bryant C.; Liu, Gang; Qian, Zhiyong*; Chen, Xiaoyuan*, Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy,ACS Nano2017,11(5), 5062-5069.
32.Chen, Wei; Wang, Fang; Zhang, Xu; Hu, Jing; Wang, Xiaokun; Yang, Ke; Huang, Liyan; Xu, Meng; Li, Qingshan; Fu, Liwu*, Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan–drug nanocomplex,J. Mater. Chem. B2016,4(41), 6652-6661.
33.Rao, Yuefeng#; Chen, Wei#; Liang, Xingguang; Huang, Yongzhuo; Miao, Jing; Liu, Lin; Lou, Yan; Zhang, Xingguo; Wang, Ben; Tang, Ruikang; Chen, Zhong; Lu, Xiaoyang*, Epirubicin‐loaded superparamagnetic iron‐oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier,Small2015,11(2), 239-247.
34.Chen, Wei; Liu, Xueyao; Xiao, Yun; Tang, Ruikang*, Overcoming multiple drug resistance by spatial–temporal synchronization of epirubicin and pooled siRNAs,Small2015,11(15), 1775-1781.
35.Chen, Wei; Fu, Liwu*; Chen, Xiaoyuan*, Improving cell-based therapies by nanomodification,J. Control. Release2015,219, 560-575.
36.Chen, Wei; Wang, Guangchuan; Tang, Ruikang*, Nanomodification of living organisms by biomimetic mineralization,Nano Res.2014,7(10), 1404-1428.
37.Chen, Wei; Liu, Xueyao; Xiao, Yun; Chen, Yanhong; Wang, Guangchuan; Liu, Cuilian; Xu, Xurong; Tang, Ruikang*, Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls,Small2014,10(18), 3644-3649.
38.Chen, Wei; Xiao, Yun; Liu, Xueyao; Chen, Yanhong; Zhang, Jiaojiao; Xu, Xurong; Tang, Ruikang*, Overcoming cisplatin resistance in chemotherapy by biomineralization,Chem. Commun.2013,49(43), 4932-4934.
39.Lv, Qiying#; Li, Xiaoye#; Tian, Xin; Fu, Da‐an; Liu, Huan; Liu, Jia; Song, Yu; Cai, Bo; Wang, Jian; Su, Qiangfei; Chen, Wei; Zou, Meizhen; Xiao, Fei; Wang, Shuai*; Wang, Zheng*; Wang, Lin*, A degradable and biocompatible supercapacitor implant based on functional sericin hydrogel electrode,Adv. Energy Mater.2023, 2203814.
40.Liu, Huan; Qin, Sumei; Zhang, Hongyan; Chen, Zhongyin; Zhao, Yiwei; Liu, Jia; Deng, Yan; Liu, Miaodeng; Chen, Wei; Wang, Zheng*; Wang, Lin*, Silk sericin-based ros-responsive oxygen generating microneedle platform promotes angiogenesis and decreases inflammation for scarless diabetic wound healing,Adv. Funct. Mater.2024, 2404461.
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