何然

華中科技大學(xué)同濟(jì)醫(yī)學(xué)院 副教授

通訊地址：湖北省武漢市漢口航空路13號

郵編：430030

電話：18523010609

教育經(jīng)歷：

2012／09－2016／12，南方醫(yī)科大學(xué)，博士

2011/ 06－2012/ 08，香港理工大學(xué)，碩士

2008／02－2010／12，新西蘭奧塔哥大學(xué)，學(xué)士

工作經(jīng)歷：

2017/09至今，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院 副教授

主要榮譽：

2017年中國免疫學(xué)會青年學(xué)者獎

2016年重慶市科協(xié)首屆自然科學(xué)優(yōu)秀論文獎

主要論文：

He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature 2016 Aug 2;537(7620):412-428.

Zhao L*, He R*, Long H*, Guo B*, Jia Q, Qin D, Liu SQ, Wang Z, Xiang T, Zhang J, Tan Y, Huang J, Chen J, Wang F, Xiao M, Gao J, Yang X, Zeng H, Wang X, Hu C, Alexander PB, Symonds ALJ, Yu J, Wan Y, Li QJ, Ye L, Zhu B. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature Medicine 2018 Oct;24(10):1536-1544.

*co-first author

He R, Yang X, Liu C, Chen X, Wang L, Xiao M, Ye J, Wu Y, Ye L. Efficient control of chronic LCMV infection by CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model. Cellular and Molecular Immunology 2018 Sep;15(9):815-826.

Xia Y, Lan J, Yang J, Yuan S, Xie X, Du Q, Du H, Nie W, Jiang B, Zhao L, Cai Z, Zhang X, Xiong Y, Li Y, He R*, Tao J*. Saturated fatty acid-induced neutrophil extracellular traps contribute to exacerbation and biologic therapy resistance in obesity-related psoriasis. Cellular and Molecular Immunology 2025 Jun;22(6):597-611.

*co-responding author

Du Q, Ning N, Zhao X, Liu F, Zhang S, Xia Y, Li F, Yuan S, Xie X, Zhu M, Huang Z, Tang Z, Wang J, He R*, Yang XP*. Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response. Theranostics. 2025 Jan 1;15(4):1304-1319. doi: 10.7150/thno.101298.

*co-responding author

Xiao M, Xie L, Cao G, Lei S, Wang P, Wei Z, Luo Y, Fang J, Yang X, Huang Q, Xu L, Guo J, Wen S, Wang Z, Wu Q, Tang J, Wang L, Chen X, Chen C, Zhang Y, Yao W, Ye J, He R*, Huang J*, Ye L*. CD4+ T-cell epitope-based heterologous prime-boost vaccination potentiates antitumor immunity and PD-1/PD-L1 immunotherapy. Journal for ImmunoTherapy of Cancer 2022;0:e004022. doi:10.1136/.

*co-responding author

Li, Lin; Xia, Yuting; Yuan, Shijie; Li, Fei; Xie, Xiaorong; Luo, Yuan; Yang, Xiang-Ping; He, Ran; Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell, Journal of Leukocyte Biology 2021, 110(6): 1057-1067

Luo Y, Li D, Xie L, Lei S, Chen X, Wang C, Yao D, Li L, Fang J, Chen C, Yuan S, Li F, Xie X, Zhang Y, Li Z, Hu L, Tang J, Ye L, Wei Z, He R. EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection. Front Immunol. 2022 Aug 15;13:942465. doi: 10.3389/fimmu.2022.942465.

Zhao X, Xia M, Peng Z, Du Q, Liu Y, Xia Y, Lv P, Zhang X, Yuan S, Xie X, Wang J, Sun S, Yang XP, He R. TFEB Phase Separation Mediates the Amelioration Effect of Intermittent Fasting on Inflammatory Colitis. Inflammation. 2024 Dec 27. doi: 10.1007/s10753-024-02202-3. Epub ahead of print.

主要科研項目：

1. 國家自然科學(xué)基金面上項目：慢性病毒感染中TCF-1對CD8 T細(xì)胞耗竭的調(diào)控作用及機(jī)制研究（81871248）主持

2. 國家自然科學(xué)基金面上項目：α-氨基丁酸調(diào)控腫瘤相關(guān)巨噬細(xì)胞極化的機(jī)制研究（32070894）主持

3. 國家重點研發(fā)計劃, 2020YFA0804400, 膽汁酸肝腸循環(huán)對腸道組織損傷修復(fù)的調(diào)控機(jī)制, 課題骨干

4. 國家重點研發(fā)計劃，2023YFC2308602，傳染病免疫耗竭期的臨床診治方案研究，課題骨干

聯(lián)系方式：ranhecl13@163.com