劉超紅，華中科技大學(xué)附屬同濟(jì)醫(yī)院過(guò)敏與臨床免疫研究所副所長(zhǎng)，同濟(jì)兒童醫(yī)院兒研所副所長(zhǎng)，基礎(chǔ)醫(yī)學(xué)院微生物系教授，科研副主任，2017年國(guó)家自然科學(xué)基金優(yōu)秀青年基金獲得者，湖北省創(chuàng)新群體項(xiàng)目負(fù)責(zé)人。2003年于武漢大學(xué)獲理學(xué)學(xué)士學(xué)位，2006年于中科院武漢病毒所獲碩士學(xué)位。2013于美國(guó)馬里蘭大學(xué)帕克分校獲博士學(xué)位。2013以研究助理加入到圣裘德兒童研究醫(yī)院遲洪波實(shí)驗(yàn)室。現(xiàn)在主要研究領(lǐng)域是呼吸和血液系統(tǒng)免疫相關(guān)疾病。研究方向包括兒童免疫缺陷性肺炎和自身免疫疾病的免疫異常機(jī)制，呼吸道病毒感染所導(dǎo)致的宿主免疫系統(tǒng)紊亂以及哮喘產(chǎn)生的機(jī)制。以通訊作者發(fā)表43篇SCI論文。其工作在Immunity、 Blood、Journal of Allergy and Clinical Immunology、Nature Communications、Science Advances、PLos Biology、 Leukemia、 Journal of Experimental Medicine、 Cell report 和Journal of Immunology等雜志發(fā)表。任中國(guó)生理學(xué)會(huì)血液分會(huì)委員，亞太醫(yī)學(xué)生物免疫學(xué)會(huì)基礎(chǔ)免疫學(xué)分會(huì)副秘書(shū)長(zhǎng)，湖北省生物免疫學(xué)會(huì)轉(zhuǎn)化醫(yī)學(xué)專委會(huì)副主委，Journal of Clinical and Translational Hepatology 雜志Associate editor和Journal of Leukocyte Biology編輯。擔(dān)任Signal Transduction and Targeted Therapy、Cellular and Molecular Immunology和eLife等雜志審稿人。以負(fù)責(zé)人身份承擔(dān)了國(guó)家重點(diǎn)研發(fā)計(jì)劃和國(guó)際合作項(xiàng)目等7項(xiàng)國(guó)家級(jí)項(xiàng)目,參與3項(xiàng)重點(diǎn)研發(fā)計(jì)劃。以第一完成人獲湖北省自然科學(xué)獎(jiǎng)二等獎(jiǎng)，培養(yǎng)了數(shù)名博士后和研究生，獲校三育人積極分子和優(yōu)秀研究生導(dǎo)師稱號(hào)。

聯(lián)系方式：chaohongliu80@126.com

發(fā)表文章

(^#Co-first author ,*Co-corresponding author)

Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin's lymphoma via CCR7/ARHGAP18/IKBαsignaling activation.Wang J^#, Tao Q^#, Huang K^#, Wang Y, Hu L, Ren A, Wang H, Wan Y, Li J, Yi L, Ruan Y, Wanyan Z, Wu F, Zhai Z*,Liu C*.J Immunother Cancer. 2025 Jan 7;13(1):e009356. doi: 10.1136/jitc-2024-009356.IF=10.9

PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma.Zhang P^#, Ruan C^#, Yang G^#, Guan Y, Zhu Y, Li Q, Dai X, An Y, Shi X, Huang P, Chen Y, He Z*, Du Z*,Liu C*.Adv Sci (Weinh). 2024 Dec;11(45):e2403939. doi: 10.1002/advs.202403939. Epub 2024 Oct 16.IF=14.3

DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells.Gu H^#, Xie M^#, Zhao S, Luo X, Huang Y, Yang L, Guan F, Lei J*,Liu C*.Cell Death Dis. 2024 Dec 1;15(11):871. doi: 10.1038/s41419-024-07180-w.IF=9.685

Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4⁺T cells.Jiang P^#, Zhao S^#, Li X, Hu S, Chen S, Liang Y, Zhang L, Lu L, Fang G, Yang L, Huang Y, Miller H, Guan F, Lei J,Liu C.MedComm (2020). 2024 Sep 25;5(10):e747. doi: 10.1002/mco2.747. eCollection 2024 Oct.IF=10.7

The interaction of innate immune and adaptive immune system.Wang R^#, Lan C^#, Benlagha K, Camara NOS, Miller H, Kubo M, Heegaard S, Lee P, Yang L, Forsman H, Li X*, Zhai Z*, Liu C*.MedComm (2020). 2024 Sep 15;5(10):e714. doi: 10.1002/mco2.714. eCollection 2024 Oct.IF=10.7

Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.Liu JC^#, Zhang K^#, Zhang X, Guan F, Zeng H, Kubo M, Lee P, Candotti F, James LK, Camara NOS, Benlagha K, Lei JH, Forsman H, Yang L, Xiao W*, Liu Z*,Liu CH*.MedComm (2020). 2024 Aug 13;5(8):e662. doi: 10.1002/mco2.662. eCollection 2024 Aug.IF=10.7

Jiang P, Jing Y, Zhao S, Lan C, Yang L, Dai X, Luo L, Cai S, Zhu Y, Miller H, Lai J, Zhang X, Zhao X, Wu Y, Yang J, Zhang W, Guan F, Zhong B, Umehara H, Lei J, Dong L*,Liu C*.Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. Nat Commun. 2024 Mar 23;15(1):2627. doi: 10.1038/s41467-024-45977-7. PMID: 38521787; PMCID: PMC10960850.IF=16.6

Yu H^#, Yang L^#, Han Z, Zhou X, Zhang Z, Sun T, Zheng F, Yang J, Guan F, Xie J,Liu C. SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. J Med Virol. 2023 Dec;95(12):e29270. doi: 10.1002/jmv.29270. PMID: 38047459.IF=12.7

Yang Y, Miller H, Byazrova MG, Cndotti F, Benlagha K, Camara NOS, Shi J, Forsman H, Lee P, Yang L, Filatov A*, Zhai Z*,Liu C*. The characterization of CD8+ T-cell responses in COVID-19. Emerg Microbes Infect. 2024 Dec;13(1):2287118. doi: 10.1080/22221751.2023.2287118. Epub 2024 Jan 11. PMID: 37990907; PMCID: PMC10786432.IF=13.2

Gu H, Fu Y, Yu B, Luo L, Kang D, Xie M, Jing Y, Chen Q, Zhang X, Lai J, Guan F, Forsman H, Shi J, Yang L, Lei J, Du X, Zhang X*,Liu C*. Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR signaling. MedComm (2020). 2023 Oct 1;4(5):e379. doi: 10.1002/mco2.379. PMID: 37789963; PMCID: PMC10542999.IF=10.1

Wang X, Guan F, Miller H, Byazrova MG, Cndotti F, Benlagha K, Camara NOS, Lei J, Filatov A*,Liu C*. The role of dendritic cells in COVID-19 infection. Emerg Microbes Infect. 2023 Dec;12(1):2195019. doi: 10.1080/22221751.2023.2195019. PMID: 36946172; PMCID: PMC10171120.IF=13.2

Yu H, Guan F, Miller H, Lei J,Liu C. The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development. Emerg Microbes Infect. 2022 Dec 30:2164219.IF=13.2

Du Z, Huang L, Dai X, Yang D, Niu L, Miller H, Ruan C, Li H, Hu L, Zhou L, Jian D, Sun J, Shi X, Huang P, Chen Y, Zhao X*,Liu C*. Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF. Cell Death Differ. 2022 Oct;29(10):1901-1912.IF=12.074

Zhu Y^#, Gu H^#, Yang L, Li N, Chen Q, Kang D, Lin S, Jing Y, Jiang P, Chen Q, Luo L, Liu J, Chang J, Li Z, Wang Y, Dai X, Miller H, Westerberg LS, Park CS, Kubo M, Gong Q, Dong L*,Liu C*. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2.Clin Transl Med. 2022 Jul;12(7):e887.IF=10.6

Dai Z^#, Mu W^#, Zhao Y, Cheng J, Lin H, Ouyang K, Jia X, Liu J, Wei Q, Wang M,Liu C, Tan T, Zhou J. T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape. Signal Transduct Target Ther. 2022 Mar 25;7(1):85.IF=38.120

He M*, Saeed MB, Record J, Keszei M, Gon?alves Pinho L, Vasconcelos-Fontes L, D'Aulerio R, Vieira R, Oliveira MMS, Geyer C, Bohaumilitzky L, Thiemann M, Deordieva E, Buedts L, Matias Lopes JP, Pershin D, Hammarstr?m L, Xia Y, Zhao X, Cunningham-Rundles C, Thrasher AJ, Burns SO, Cotta-de-Almeida V,Liu C, Shcherbina A, Vandenberghe P, Westerberg LS*. Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation. J Allergy Clin Immunol. 2022 Mar;149(3):1069-1084.IF=14.291、

Jing Y^#, Luo L^#, Chen Y, Westerberg LS, Zhou P, Xu Z, Herrada AA, Park CS, Kubo M, Mei H, Hu Y, Lee PP, Zheng B, Sui Z, Xiao W, Gong Q, Lu Z*,Liu C*.SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism. Signal Transduct Target Ther. 2021 Sep 22;6(1):345.IF=38.120

Yang L, Li N, Yang D, Chen A, Tang J, Jing Y, Kang D, Jiang P, Dai X, Luo L, Chen Q, Chang J, Liu J, Gu H, Huang Y, Chen Q, Li Z, Zhu Y, Miller H, Chen Y, Qiu L, Mei H, Hu Y, Gong Q,Liu C*. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death and Differentiation.2021 Sep;28(9):2616-2633.IF=10.717

Herrada AA*, Olate-Briones A, Rojas A,Liu C, Escobedo N, Piesche M*.Adipose tissue macrophages as a therapeutic target in obesity-associated diseases.Obes Rev. 2021 Jun;22(6):e13200.IF=9.213

Wang ZZ, Song J, Wang H, Li JX, Xiao Q, Yu Z, Wang ZC, Liu JX, Pan L, Yao Y, Chen CL, Lu X,Liu C, Gao P, Liu Z*. Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps. Allergy. 2021 May;76(5):1416-1431.IF=13.146

Du Z^#, Chen A^#, Huang L, Dai X, Chen Q, Yang D, Li L, Miller H, Westerberg L, Ding Y, Tang X, Kubo M, Jiang L, Zhao X*, Wang H*,Liu C*. STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production. J Allergy Clin Immunol. 2021 May;147(5):1907-1923.e6.IF=10.228

Wang L^#, Jiang P^#, Zhao S, Liu H, Liu L, Mor G,Liu C*, Liao A*. The dynamic profile and potential function of B-cell subsets during pregnancy. Cell Mol Immunol. 2021 Apr;18(4):1082-1084.IF=22.096

Raynor JL,Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H*.Hippo/Mst Signaling Coordinates Cellular Quiescence with Terminal Maturation in iNKT Cell Development and Fate Decisions. J Exp Med. 2020 Jun 1;217(6): e20191157.IF=11.743

Jing Y^#, Dai X^#, Yang L^#, Kang D, Jiang P, Li N, Cheng J, Li J, Miller H, Ren B, Gong Q, Yin W, Liu Z, Mattila P, Ning Q, Sun J, Yu B* andLiu C*.STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020 Apr 22; 6(17): eaax9455.*Co-corresponding author. IF=13.116

Jing Y^#, Kang D^#, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H,Liu Z, Zhu X, Yang J, Wang X, Sun J*,Liu Z*, Liu W*, Zhou X*,Liu C*.Dock2 couples with LEF-1 to regulate the expression of CD21 and B cell differentiation.Journal of Allergy and Clinical Immunology.2019 Nov; 144(5): p. 1377-1390 e4.*Co-corresponding author.IF=14.11

Xu C, Fang Y, Yang Z, Jing Y, Zhang Y,Liu C*,Liu W*.MARCKS Regulates Tonic and Chronic Active B Cell Receptor Signaling.Leukemia.2019 Mar;33(3):710-729.*Co-corresponding author.IF=9.944

Shi H,Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W*, Chi H*. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R–STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018 Nov 20; 49 (5): 899-914.e6.IF=19.734

Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, Sun X, Bai X, Xuan X, Li Q, Shi C, Yu B, Miller H, Yang G, Westerberg LS, Liu W, Song W, Zhao X*,Liu C*.Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLos Biology. 2017 Aug 18; 15(8): e2001750.*Co-corresponding author. IF=9.797

Bai X, Zhang Y, Huang L, Wang J, Li W, Niu L, Jiang H, Dai R, Zhou L, Zhang Z, Miller H, Song W, Zhao X,Liu C*.The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 down regulation. Blood.2016 Sep 29; 128(13):1723-34.IF=11.847

Zhang X^#, Dai R^#, Li W, Zhao H, Zhang Y, Zhou L, Du H, Luo G, Wu J, Niu L, An Y, Zhang Z, Ding Y, Song W,Liu C, Zhao X*.Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome. Blood.2016 Jun 23; 127(25):3180-91.IF=11.847

Song W*,Liu C, Seeley-Fallen MK, Miller H, Ketchum C, Upadhyaya A. Actin-mediated feedback loops in B-cell receptor signaling. Immunological Reviews. 2013 Nov; 256(1):177-89.IF=12.909

Liu C, Bai X, Wu J, Sharma S, Upadhyaya A,Dahlberg C, Westerberg L,Snapper S, Zhao X, Song W*.N-WASP is Essential for the Negative Regulation of B cell Receptor Signaling. Plos Biology. 2013 Nov; 11(11): e1001704.IF=11.771

Becker-Herman S^#, Meyer-Bahlburg A^#, Schwartz M^#, Jackson S, Hudkins K,Liu C, Sather B, Khim S, Liggitt D, Song W, Silverman G, Alpers C, Rawlings D*. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.Journal of Experimental Medicine. 2011 Sep 26; 208(10):2033-42.IF=11.743

承擔(dān)課題

1、以B細(xì)胞代謝信號(hào)通路為靶向的抗新冠病毒藥物的篩選 人畜共患傳染病重癥診治全國(guó)重點(diǎn)實(shí)驗(yàn)室 2024年01月至2025年12月 10萬(wàn) 課題負(fù)責(zé)人

2、Wiskott-Aldrich綜合征中的免疫缺陷：WASH蛋白在B細(xì)胞中的功能32311530061 國(guó)家自然科學(xué)基金委員會(huì),國(guó)際(地區(qū))合作與交流項(xiàng)目2023-05-01至2025-04-30 10萬(wàn) 課題負(fù)責(zé)人

3、原發(fā)性免疫缺陷病高IgE的發(fā)病機(jī)制和治療研究2021YFE0108200政府間國(guó)際科技創(chuàng)新合作 2021年07月 至2024年06月 273萬(wàn) 課題負(fù)責(zé)人

4、兒童罕見(jiàn)病診斷關(guān)鍵技術(shù)與治療靶點(diǎn)發(fā)現(xiàn)及轉(zhuǎn)化醫(yī)學(xué)研究 2023YFC2706300 科技部重點(diǎn)研發(fā)項(xiàng)目 2023年12月-2026年11月 20萬(wàn) 課題參與人

5、各亞型慢性鼻炎發(fā)病機(jī)制研究2023YFC2507900 科技部重點(diǎn)研發(fā)項(xiàng)目 2023年11月-2026年10月234萬(wàn) 子課題負(fù)責(zé)人

6、不同SARS-CoV-2變種感染中體液免疫的動(dòng)態(tài)分析和應(yīng)答機(jī)制研究NSFC82371784課題負(fù)責(zé)人國(guó)家自然科學(xué)基金面上項(xiàng)目2024-01-01至2027-12-3149萬(wàn)課題負(fù)責(zé)人

7、新冠病毒感染機(jī)體免疫應(yīng)答平衡及肺臟區(qū)域免疫特征研究 SRPG22-006 廣州國(guó)家實(shí)驗(yàn)室項(xiàng)目200萬(wàn)課題參與人

8、以WASp蛋白為靶向的慢性病和免疫缺陷的治療 NSFC81861138002中瑞國(guó)際合作項(xiàng)目2018-01-01至2020-12-31300萬(wàn)課題負(fù)責(zé)人

9、創(chuàng)新提升基因修飾T細(xì)胞治療惡性實(shí)體瘤安全和有效性研究及臨床轉(zhuǎn)化2019YFC1316200 科技部慢病重點(diǎn)研發(fā)項(xiàng)目2019 年 12 月-2021 年 12 月 50萬(wàn)課題參與人

10、血液系統(tǒng)的免疫疾病 NSFC 81722002國(guó)家自然科學(xué)基金優(yōu)秀青年基金 2018年01月至 2020年12月 130萬(wàn)課題負(fù)責(zé)人

11、WASH通過(guò)促進(jìn)STAT1磷酸化調(diào)控B細(xì)胞功能的機(jī)制研究NSFC 31970839 國(guó)家自然科學(xué)基金面上項(xiàng)目2020-01-01至2023-12-3158萬(wàn)課題負(fù)責(zé)人

12、CD23調(diào)控BCR信號(hào)和肌動(dòng)蛋白重組機(jī)制的研究 NSFC 31500709國(guó)家自然科學(xué)基金青年基金項(xiàng)目 2016-01-01至2018-12-3122萬(wàn)課題負(fù)責(zé)人

主要著作

“B cell receptor signaling”, Methods in Molecular Biology, Springer， 2017

“Tcell receptor signaling”, Methods in Molecular Biology, Springer， 2020

“Invariant Natural Killer T cells”, Methods in Molecular Biology, Springer， 2021