魯友明個(gè)人簡(jiǎn)介

1998年畢業(yè)于多倫多大學(xué)，獲神經(jīng)科學(xué)博士學(xué)位。2010年3月獲聘中組部國(guó)家特聘專(zhuān)家，辭去美國(guó)路易斯安那州立大學(xué)新奧爾良醫(yī)學(xué)中心BOLLINGER冠名終身正教授，全職在華中科技大學(xué)同濟(jì)醫(yī)學(xué)院工作至今。現(xiàn)任同濟(jì)醫(yī)學(xué)院副院長(zhǎng)、教育部腦醫(yī)學(xué)基礎(chǔ)研究創(chuàng)新中心主任。

魯友明教授長(zhǎng)期致力于解析“記憶分子和環(huán)路機(jī)制”。他的主要學(xué)術(shù)貢獻(xiàn)是提出了“靶向腫瘤分泌因子治療阿爾茨海默病”的新理論。在Cell，Science，Nature Neuroscience和Neuron等期刊發(fā)表研究論文150篇，總引用超過(guò)13,000次，入選“愛(ài)思唯爾2014-2024年度”神經(jīng)科學(xué)領(lǐng)域高被引中國(guó)學(xué)者，2021年中國(guó)神經(jīng)科學(xué)學(xué)會(huì)“CST杰出神經(jīng)科學(xué)家獎(jiǎng)”。部分成果被諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)得主John O′Keefe教授寫(xiě)入教科書(shū)。“記憶神經(jīng)環(huán)路與分子機(jī)制”獲2021年湖北省自然科學(xué)獎(jiǎng)一等獎(jiǎng)，基金委“記憶神經(jīng)環(huán)路機(jī)制”創(chuàng)新研究群體，教育部首屆“黃大年式教師團(tuán)隊(duì)”（牽頭人）。科技部“神經(jīng)環(huán)路結(jié)構(gòu)與功能學(xué)科創(chuàng)新基地”（負(fù)責(zé)人）。主編中國(guó)普通高等教育“十四五”規(guī)劃教材《生理學(xué)》和教育部 101 計(jì)劃核心教材《神經(jīng)系統(tǒng)》。

郵箱：lym@hust.edu.cn

代表論文（通訊和共同通訊）：

1. Li X, Tang X, Zeng J, Duan L, Hou Z, Li L, Guo Y, Chai C, Wang Y, Liu J, Wang Y, Zhu LQ, Lu Y. Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2. Cell 2026 (in press）

2. He A, Wang Y, Shen Y, Dong Z, Luo L, Ge X, Liu X, Mao Y, Zhang T, Li X, Li H, Jing W, Zhu L, Zhang Q, Lu Y. Allosteric activation of a cell-type specific GPR120 inhibits amyloid pathology of Alzheimer’s disease. Nature Aging 2025 2025 Dec 19. doi: 10.1038/s43587-025-01028-4.

3. Zhou Y, Li WL, Liu ZQ, Ai WQ, Kou JX, Fan HW, Han ZT, Hu YZ, Zhang HH, Jia JJ, Zeng Y, Guo ZY, Man HY, Lu Y, Liu D, Zhu LQ. Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons. Nature Neuroscience 2025 Nov 18. doi: 10.1038

4. Qin P, Zhao W, Zhou X, Guo Y, Li L, Liu Z, Shen X, Yang C, Tang X, Yu D, Zhu M, Wu S, Cheng L, Yang J, Li X, Li H, Zhu LQ, Jing W, Du HY, Liu D, Lu Y. A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1. Science Advances 2025 Jun 6;11(23): eadt5400. doi: 10.1126

5. Luo L, Jing W, Guo Y, Liu D, He A, Lu Y. A cell-type-specific circuit of somatostatin neurons in the habenula encodes antidepressant action in male mice. Nature Communications 2025 Apr 10;16(1):3417. doi: 10.1038

6. Li L, Guo Y, Jing W, Tang X, Zeng J, Hou Z, Song Y, He A, Li H, Zhu LQ, Lu Y, Li X. Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory. Advanced Science (2025) Feb 10:e2409397.

7. Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C. Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release. Science Advances 10(20) (2024): eadi7024.

8. Li X, Yu H, Zhang B, Li L, Chen W, Yu Q, Huang X, Ke X, Wang Y, Jing W, Du H, Li H, Zhang T, Liu L, Zhu LQ, Lu Y. Molecularly defined and functionally distinct cholinergic subnetworks. Neuron 110(22) (2022):3774-3788.e7

9. He A, Zhang C, Ke X, Yi Y, Yu Q, Zhang T, Yu H, Du H, Li H, Tian Q, Zhu LQ, Lu Y. VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription. Science China Life Sciences. 65(8) (2022): 1590-1607

10. Li X, Chen W, Huang X, Jing W, Zhang T, Yu Q, Yu H, Li H, Tian Q, Ding Y, Lu Y. Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors. Molecular Neurodegeneration. 16(1) (2021): 73.

11. Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ, Lu Y. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nature Neuroscience. 21(9) (2018): 1239-1250

12. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. A novel mechanism of memory loss in Alzheimer's disease mice via the degeneration of entorhinal-CA1 synapses. Molecular Psychiatry. 23(2) (2018): 199-210.

13. Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nature Communications. 8(1) (2017): 1676.

14. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 73(4) (2012): 774-788

15. Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian MM, Balel C, Wang M, Jia N, Zhang W, Lew F, Chan SL, Chen Y, Lu Y. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. 140(2) (2010): 222-234