雷家慧，醫(yī)學(xué)博士，病原生物學(xué)系教授，哈佛大學(xué)訪問學(xué)者。

主要研究方向為病原感染免疫學(xué)、蟲源性分子對免疫性疾病的調(diào)控作用和應(yīng)用以及肝纖維化的免疫調(diào)控機制。主持國家和省部課題8項，參與科技部國家重點研發(fā)項目、國家自然基金、973和863基金等10余項。發(fā)表中英文論文 50 余篇，論文先后獲得武漢市優(yōu)秀科技論文獎二等獎和三等獎。先后擔(dān)任人民衛(wèi)生出版社公共衛(wèi)生與預(yù)防醫(yī)學(xué)“101 計劃”《 病原生物與免疫學(xué)》、全國高等醫(yī)學(xué)教育臨床醫(yī)學(xué)專業(yè)課程思政案例庫《人體寄生蟲學(xué)》、《臨床寄生蟲病學(xué)》第二版和《人體寄生蟲學(xué)》第八版電子教材編委。擔(dān)任中華醫(yī)學(xué)會熱帶病與寄生蟲學(xué)分會青年委員、中華預(yù)防醫(yī)學(xué)會醫(yī)學(xué)寄生蟲學(xué)分會青年委員、湖北省熱帶病與寄生蟲學(xué)學(xué)會主任委員、湖北省預(yù)防醫(yī)學(xué)會寄生蟲學(xué)專業(yè)委員會常務(wù)委員、湖北省血吸蟲病咨詢委員會委員和武漢市預(yù)防醫(yī)學(xué)會寄生蟲學(xué)委員會副主任委員。兼任《中華地方病學(xué)雜志》、《Zoonoses》和《熱帶病與寄生蟲學(xué)》雜志編委。

聯(lián)系方式：leijiahui@hust.edu.cn

近5年主要發(fā)表文章（#第一作者；*通訊作者）：

1. Gu H#, Xie M#, Zhao S, Luo X, Huang Y, Yang L, Guan F, Lei J*, Liu C*. DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells. Cell Death Dis 2024; 15(11):871. doi:10.1038/s41419-024-07180-w.

2. Zhu F#, Zheng W#, Gong Y, Zhang J, Yu Y, Zhang J, Liu M, Guan F*, Lei J*. Trichinella spiralis Infection Inhibits the Efficacy of RBD Protein of SARS-CoV-2 Vaccination via Regulating Humoral and Cellular Immunity. Vaccines (Basel). 2024 Jun 30;12(7):729. doi: 10.3390/vaccines12070729.

3. Zhu H#, Deng W, Guan F, Lei J*. Development of the WeChat Public Account I Love Parasitology and its Preliminary Application in the Teaching of Human Parasitology. J Med Educ Curric Dev. 2024 May 26:11:23821205241255224. doi: 10.1177/23821205241255224.

4. Lei J#, Feng Y, Zheng W, Khamis M, Zhang J, Hou X, Guan F*. Type I/II Immune Balance Contributes to the Protective Effect of AIF-1 on Hepatic Immunopathology Induced by Schistosoma japonicum in a Transgenic Mouse Model. Inflammation. 2024 Mar 30. doi: 10.1007/s10753-024-02010-9.

5. Guan F#, Luo X, Liu J, Huang Y, Liu Q, Chang J, Fang G, Kang D, Gu H, Luo L, Yang L, Lin Z, Gao X, Liu C, Lei J*. GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells. iScience. 2023 Jul 16;26(8):107341. doi: 10.1016/j.isci.2023.107341.

6. Hou X#, Zhu F, Zheng W, Jacques ML, Huang J, Guan F, Lei J*. Protective effect of Schistosoma japonicum eggs on TNBS-induced colitis is associated with regulating Treg/Th17 balance and reprogramming glycolipid metabolism in mice. Front Cell Infect Microbiol. 2022 Oct 11:12:1028899. doi: 10.3389/fcimb.2022.1028899.

7. Zhu F#, Liu W, Liu T, Shi L, Zheng W, Guan F, Lei J*. A New Role for Old Friends: Effects of Helminth Infections on Vaccine Efficacy. Pathogens. 2022 Oct 8;11(10):1163. doi: 10.3390/pathogens11101163.

8. Lei JH#, Guan F, Zhu HG, Liu WQ*. Online education in human parasitology during the COVID-19 pandemic in Wuhan: Our experiences, challenges, and perspectives. Zoonoses, 2022, 2(1): 1.

9. Bai Y#, Guan F#, Zhu F, Jiang C, Zheng F, Liu W, Lei J*. IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. J Inflamm Res. 2021 Nov 15:14:5981-5998. doi: 10.2147/JIR.S336404.

10. Xin C#, Lei J#, Wang Q, Yin Y, Yang X, Moran Guerrero JA, Sabbisetti V, Sun X, Vaidya VS*, Bonventre JV*. Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease. iScience. 2021 Sep 29;24(10):103193. doi: 10.1016/j.isci.2021.103193.

11. Guan F#, Jiang W, Bai Y, Hou X, Jiang C, Zhang C, Jacques ML, Liu W, Lei JH *. Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages. Infect Immun. 2021 Apr 16;89(5):e00683-20. doi: 10.1128/IAI.00683-20.

12. Guan F#, Zhang C, Jiang C, Jacques ML, Bai Y, Lu S, Liu W, Lei JH*. ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica. Parasite Immunol. 2020 Dec;42(12):e12785. doi: 10.1111/pim.12785.

13. Jacques M#, Mahamane Salissou M, Kaswiyi L, Guan F, Lei JH*. Co-infection of malaria and HIV infection in severely undernourished children in the Democratic Republic of the Congo: a cross-sectional study. Parasitology. 2020 Feb;147(2):248-253. doi: 10.1017/S0031182019001513.

14. Langston PK#, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei JH, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T*. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nat Immunol. 2019 Sep;20(9):1186-1195. doi: 10.1038/s41590-019-0453-7.