明章銀，博士，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院藥理學(xué)系教授，博士生導(dǎo)師，系副主任，美國(guó)威斯康星血液中心血液研究所博士后，中國(guó)藥理學(xué)會(huì)理事，中國(guó)藥理學(xué)會(huì)心血管藥理專委會(huì)常務(wù)理事、生化與分子藥理學(xué)專委會(huì)委員，中國(guó)生理學(xué)會(huì)血栓與止血專業(yè)委員會(huì)委員，中華中醫(yī)藥學(xué)會(huì)中藥實(shí)驗(yàn)藥理分會(huì)委員，湖北省藥理學(xué)會(huì)副理事長(zhǎng)，湖北省藥學(xué)會(huì)常務(wù)委員，國(guó)際血栓與止血學(xué)會(huì)（ISTH）會(huì)員。主持國(guó)家自然科學(xué)基金面上項(xiàng)目5項(xiàng)及裝備預(yù)研教育部聯(lián)合基金1項(xiàng)，主持及參與國(guó)家科技部科技攻關(guān)項(xiàng)目、省廳項(xiàng)目等部委課題研究多項(xiàng)，獲教育部科技進(jìn)步一等獎(jiǎng)1項(xiàng)，湖北省自然科學(xué)三等獎(jiǎng)1項(xiàng)，獲湖北省第十四屆自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng)，獲美國(guó)威斯康星血液中心血液研究所優(yōu)秀Postdoctoral Fellow榮譽(yù)證書(shū)，入選湖北省“創(chuàng)新創(chuàng)業(yè)戰(zhàn)略團(tuán)隊(duì)”學(xué)術(shù)帶頭人。承擔(dān)本科生、八年制及研究生的理論課及實(shí)驗(yàn)課教學(xué)，指導(dǎo)的本科學(xué)生科研小組在第二屆全國(guó)大學(xué)生基礎(chǔ)醫(yī)學(xué)創(chuàng)新論壇暨實(shí)驗(yàn)設(shè)計(jì)大賽中榮獲一等獎(jiǎng)，參與科學(xué)出版社出版的《藥理學(xué)實(shí)驗(yàn)指導(dǎo)》編寫(xiě)。擔(dān)任教育部學(xué)位與研究生教育評(píng)估專家、國(guó)家藥品監(jiān)督管理局藥品審評(píng)中心咨詢專家、國(guó)家藥品監(jiān)督管理局醫(yī)療器械技術(shù)審評(píng)中心專家，British Journal of Pharmacology、Acta Pharmacologica Sinica、Journal of Thrombosis and Haemostasis及《中國(guó)藥理學(xué)及毒理學(xué)雜志》 特約審稿人，在Blood、Hypertension、Cancer Letters，Thrombosis Research、Cell Death Dis，Acta Pharmacol Sin，Molecular Nutrition & food Research等期刊發(fā)表論文60余篇。

主要研究方向：

1.血小板粘附激活的分子機(jī)制

2.血小板在腫瘤和心腦血管等疾病中的作用及機(jī)制和干

預(yù)靶點(diǎn)

3.新藥開(kāi)發(fā)與評(píng)價(jià)（中藥藥理）

聯(lián)系方式：Email：zyming@hust.edu.cn

科研項(xiàng)目：

1. GPVI/Galectin-3介導(dǎo)血小板-平滑肌細(xì)胞交互對(duì)話在肺動(dòng)脈高壓中的作用及機(jī)制研究，項(xiàng)目負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目，No.82370139，2024.1-2027.12

2. ADAM10-CX3CL1軸在血小板促進(jìn)肝癌轉(zhuǎn)移中的作用及機(jī)制研究，項(xiàng)目負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目，No.82170132，2022.1-2025.12

3. 血小板膜受體GPVI在急性腎損傷中的作用和機(jī)制研究，項(xiàng)目負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目，No.81970129，2020.1-2023.12

4. 戰(zhàn)場(chǎng)創(chuàng)傷出血的快速止血研究，項(xiàng)目負(fù)責(zé)人，裝備預(yù)研教育部聯(lián)合基金，在研6141A02022633

5. FcγRIIa介導(dǎo)的血小板激活及KLF6在血小板促肝癌生長(zhǎng)和轉(zhuǎn)移中的作用及機(jī)制研究，項(xiàng)目負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目，No.81473270，已結(jié)題

6. 血小板FcγRIIa介導(dǎo)αIIbβ3 "由外向內(nèi)"信號(hào)轉(zhuǎn)導(dǎo)機(jī)制研究，項(xiàng)目負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目,No.81273574已結(jié)題

7. 糖蛋白VI介導(dǎo)的腫瘤誘導(dǎo)血小板活化在肝癌中的作用研究， 指導(dǎo)，No.81800133

8. 丹參新酮對(duì)血小板的作用及其機(jī)制研究，項(xiàng)目負(fù)責(zé)人，湖北省衛(wèi)生計(jì)生委中醫(yī)藥重點(diǎn)項(xiàng)目，在研

9. 血小板在急性腎損傷中的功能變化及其與腎損傷發(fā)展關(guān)系的研究，項(xiàng)目負(fù)責(zé)人，湖北省科技廳重點(diǎn)實(shí)驗(yàn)室項(xiàng)目，在研

10. 血竭黃酮類化合物抗血小板功能及機(jī)制研究，項(xiàng)目負(fù)責(zé)人，湖北省自然科學(xué)基金,已結(jié)題

11. 甲基蓮心堿對(duì)血小板負(fù)性作用的研究，項(xiàng)目負(fù)責(zé)人，湖北省自然科學(xué)基金,已結(jié)題

12. 白楊素抗血小板作用的機(jī)制研究，項(xiàng)目負(fù)責(zé)人，武漢市科技局國(guó)際科技合作重點(diǎn)計(jì)劃，已結(jié)題

13. 重組蛇毒蛋白酶抗栓作用的臨床前研究，項(xiàng)目負(fù)責(zé)人，武漢市科技局重點(diǎn)科技攻關(guān)項(xiàng)目及湖北省衛(wèi)生廳科研項(xiàng)目，已結(jié)題

14. 臨床常用抗栓治療方案對(duì)血小板形態(tài)與功能的研究，項(xiàng)目負(fù)責(zé)人，自主創(chuàng)新基金重點(diǎn)專項(xiàng)，已結(jié)題

    發(fā)表論文：（*Corresponding author）

15. Lu M, Gong X, Zhang YM, Guo YW, Zhu Y, Zeng XB, Gao JH, Liu LM, Shu D, Ma R, Liang HF, Zhang RY, Xu Y, Zhang BX, Lu YJ, Ming ZY.Platelets promote primary hepatocellular carcinoma metastasis through TGF-β1-mediated cancer cell autophagy.Cancer Lett.2024 Sep 28:600:217161. doi:10.1016/j.canlet.2024.217161.

16. Gao JH, He AD, Liu LM, Zhou YJ, Guo YW, Lu M, Zeng XB, Gong X, Lu YJ, Liang HF, Zhang BX, Ma R, Zhang RY,Ming ZY*(明章銀).Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.Cancer Lett.2024 Mar31:585:216674. doi: 10.1016/j.canlet.2024.216674.

17. Liu S, Guo F, Zhang T, Zhu Y, Lu M, Wu X, He F, Yu R, Yan D*, Ming Z*, Shu D*.Iron deficiency anemia and platelet dysfunction: A comprehensive analysis of the underlying mechanisms.Life Sci. 2024 Aug 15:351:122848.doi:10.1016/j.lfs.2024.122848.

18. Zhu Y, Shu D, Gong X, Lu M, Feng Q, Zeng XB, Zhang H, Gao J, Guo YW, Liu L, Ma R, Zhu L, Hu Q,Ming ZY*(明章銀).Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation.Hypertension.2022 May;79(5):932-945.（IF = 10.190）

19. Xu Y,Ming ZY*(明章銀).Risk Assessment and Regulatory Exploration of the Lubrication Coating on Intravascular Medical Devices.Front Cardiovasc Med.2022 May 27;9:883406.（IF =5.846）

20. Shu D, Zhu Y, Lu M, He AD, Chen JB, Ye DS, Liu Y, Zeng XB, Ma R,Ming ZY*(明章銀).Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation.Biomedicines.2021 Apr 21;9(5):444.（IF =6.081）

21. Miao S, Lu M, Liu Y, Shu D, Zhu Y, Song W, Ma Y, Ma R, Zhang B, Fang C,Ming ZY*(明章銀).Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.Mol Oncol. 2020 Oct;14(10):2546-2559.（IF=6.603）

22. Yang RP, Zhou YJ, Song W, Yin Z, He AD,Ming ZY*(明章銀).Pharmacological actions of neferine in the modulation of human platelet function.Eur J Pharmacol. 2019 Nov 5;862:172626.（IF = 4.432）

23. Song W, Ma YY, Miao S, Yang RP, Zhu Y, Shu D, Lu M, Ma R,Ming ZY*(明章銀).Pharmacological actions of miltirone in the modulation of platelet function.Acta Pharmacol Sin.2019 Feb;40(2):199-207.(IF= 6.150)

24. Miao S, Shu D, Zhu Y, Lu M, Zhang Q, Pei Y, He AD, Ma R, Zhang B,Ming ZY*(明章銀).Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa.Cell Death & Disease.2019 Jan 28;10(2):87.(IF= 8.469)

25. He AD, Wang SP, Xie W, Song W, Miao S, Yang RP, Zhu Y, Xiang JZ,Ming ZY*(明章銀).Platelet derived TGF-β promotes cervical carcinoma cell growth by suppressing KLF6 expression.Oncotarget. 2017 Aug 3;8(50):87174-87181.(IF=5.16)

26. He AD, Xie W, Song W, Ma YY, Liu G, Liang ML, Da XW, Yao GQ, Zhang BX, Gao CJ, Xiang JZ,Ming ZY*(明章銀).Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6.Sci Rep.2017 Jun 21;7(1):3989.（*Corresponding author）(IF= 4.26)

27. Yin Z, Xu HJ, Yao XL, Liu G, Nie CJ, Wei H, Li C, Liang ML,Ming ZY*(明章銀), Zhang XJ*.Ambient fine particles (PM2.5 ) attenuate collagen-induced platelet activation through interference of the PLCγ2/Akt/GSK3β signalingpathway.Environ Toxicol.2017 Feb;32(2):530-540.（*co-Corresponding author）(IF= 3.19)

28. Liu G, Xie W, He AD, Da XW, Liang ML, Yao GQ, Xiang JZ, Gao CJ,Ming ZY*(明章銀).Antiplatelet activity of chrysin via inhibiting platelet αIIbβ3-mediated signaling pathway.Mol Nutr Food Res.2016 Sep;60(9):1984-93. doi: 10.1002/mnfr.201500801.（*Corresponding author）(IF=5.914)

29. Liang ML, Da XW, He AD, Yao GQ, Xie W, Liu G, Xiang JZ,Ming ZY*(明章銀).Pentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet function.Sci Rep. 2015 Jun 10;5:11142.doi: 10.1038/srep11142.（*Corresponding author）(IF= 4.379)

30. Hao HZ, He AD, Wang DC, Yin Z, Zhou YJ, Liu G, Liang ML, Da XW, Yao GQ, Xie W, Xiang JZ,Ming ZY*(明章銀).Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies.Eur J Pharmacol.2015 Jan 5;746:63-9.（*Corresponding author）(IF= 4.432)

31. Xiang K, Liu Gang, Zhou YJ, Hao HZ, Yin Z, He AD, Da XW Xiang JZ, Wang J,Ming ZY*(明章銀).2,3,5,4’- tetrahydroxystilbene -2-O-β -D- glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro.Thromb Res. 2014 Feb; 133 (2):211-7.（*Corresponding author）(IF= 3.944)

32. Zhou YJ, Xiang JZ, Yuan H, Liu H, Tang Q, Hao HZ, Yin Z, Wang J,Ming ZY*(明章銀).Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates.Thromb Res. 2013 Aug;132(2):202-10.（*Corresponding author）(IF= 3.944)

33. Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S,Ming Z（明章銀）*, Liu C*.Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats.PLoS One.2012;7(12):e52013. doi: 10.1371/journal.pone.0052013. Epub 2012 Dec 14.(*co-Corresponding Author) (IF= 3.23)

34. Ming Z(明章銀), Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK.Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.Blood.2011; 117 (14):3903-6. (IF=17.54)

35. Zhou XH, Cheng ZP, Lu M, Lin WY, Luo LL,Ming ZY(明章銀), Hu Y.Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.Acta Pharmacol Sin.2022 Aug 2. doi: 10.1038/s41401-022-00943-1.

36. Zhou X, Cheng Z, Luo L, Zhu Y, Lin W,Ming ZY(明章銀), Chen W, Hu Y.Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis.Thromb Res. 2021 May;201:23-29.

37. Zhou X, Cheng Z, Shu D, Lin W,Ming ZY(明章銀), Chen W, Hu Y.Characteristics of mortal COVID-19 cases compared to the survivors.Aging (Albany NY). 2020 Nov 21;12(24):24579-24595.

38. Feng M, Xiang JZ,Ming ZY(明章銀), Fu Q, Ma R, Zhang QF, Dun YY, Yang L, Liu H.Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats.Cardiovasc Res. 2012;93(1):60-8.

39. 宋偉，明章銀*.血小板在靜脈血栓形成及診斷中的作用研究進(jìn)展。中國(guó)藥理學(xué)通報(bào)；2017 33(7)：889-92.（*通訊作者）

40. 尹釗，郭小梅，明章銀*.阿司匹林抵抗研究進(jìn)展。醫(yī)藥導(dǎo)報(bào)；201332（8）：981-84.（*通訊作者）

    所獲獎(jiǎng)勵(lì)：

41. “倒卵葉五加總皂甙對(duì)心、腦血管疾病的防治作用”獲湖北省自然科學(xué)獎(jiǎng)三等獎(jiǎng)，參與，2004年

42. “血栓性疾病的早期診斷和靶向治療”獲教育部科技進(jìn)步一等獎(jiǎng)，參與，2016年

43. “Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood. 2011; 117 (14):3903-6.”獲湖北省第十四屆自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng)，排名第一，2012年

44. “甲基蓮心堿對(duì)凝血酶、TXA2類似物和膠原酶誘導(dǎo)的血小板聚集的抑制作用”獲第二屆全國(guó)大學(xué)生基礎(chǔ)醫(yī)學(xué)創(chuàng)新論壇暨實(shí)驗(yàn)設(shè)計(jì)大賽一等獎(jiǎng)，指導(dǎo)教師，2012年

45. 中華醫(yī)學(xué)會(huì)第十七次全國(guó)血栓與止血學(xué)術(shù)會(huì)議最佳論文獎(jiǎng)，排名第一，2019.8

    會(huì)議報(bào)告：

46. Platelets promote hepatocellular carcinoma metastasis through releasing TGF-β1-mediated cancer cell autophagy.第32屆國(guó)際血栓與止血學(xué)會(huì)2024年大會(huì)（2024ISTH），oralpresentation，泰國(guó)曼谷，2024.6.22-26

47. 腫瘤來(lái)源IgG激活血小板的機(jī)制研究.免疫球蛋白研究新進(jìn)展學(xué)術(shù)研討會(huì)，大會(huì)報(bào)告，中國(guó) 北京，2024.7.5-6

48. Platelet GPVI is a mediator ofrhabdomyolysis-induced acute kidneyinjury in mice.第十九屆世界藥理學(xué)大會(huì)（2023WCP），oral presentation，英國(guó)格拉斯哥，2023.7.2-7

49. Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.第12屆亞太血栓與止血學(xué)會(huì)學(xué)術(shù)會(huì)議(2023APSTH)，oral presentation，馬拉西亞古晉，2023.10.18-21

50. Platelet GPVI is a mediator of rhabdomyolysis-induced acute kidney injury in mice，第二屆太湖國(guó)際血栓與止血學(xué)術(shù)討論會(huì)江蘇高校血液學(xué)協(xié)同創(chuàng)新中心血栓與止血學(xué)術(shù)會(huì)議，大會(huì)報(bào)告，蘇州，2019.10.12-13

51. Cancer cell derived immunoglobulin G activates platelet via binding platelet FcγRIIa.2019年27屆ISTH會(huì)議，oral presentation,澳大利亞 墨爾本, 2019.7.6-10

52. CX3CL1/CX3CR1介導(dǎo)的血小板浸潤(rùn)抑制肝癌生長(zhǎng)，中華醫(yī)學(xué)會(huì)第17次全國(guó)血栓與止血學(xué)學(xué)術(shù)會(huì)議，大會(huì)報(bào)告，天津，2019.8.9-11

53. Platelet GPVI is a mediator of rhabdomyolysis-induced acute kidney injury in mice，第二屆太湖國(guó)際血栓與止血學(xué)術(shù)討論會(huì)江蘇高校血液學(xué)協(xié)同創(chuàng)新中心血栓與止血學(xué)術(shù)會(huì)議，大會(huì)報(bào)告，蘇州，2019.1012-13

54. Pharmacological actions of miltirone in the modulation of platelet function.2018“一帶一路”國(guó)家傳統(tǒng)藥物藥理學(xué)學(xué)術(shù)大會(huì) 大會(huì)報(bào)告 北京2018.5.6-9

55. Cancer cell derived immunoglobulin G activates platelet via binding platelet FcγRIIa.2018年?yáng)|方藥理論壇，2018年全國(guó)心腦血管藥理學(xué)術(shù)會(huì)議，分組報(bào)告，上海，2018.12.7-9

56. Cancer cell derived immunoglobulin G activates platelet via binding platelet FcγRIIa.2018年?yáng)|方藥理論壇，2018年全國(guó)心腦血管藥理學(xué)術(shù)會(huì)議，分組報(bào)告，上海，2018.12.7-9

57. Platelet derived TGF-β promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6. 2017年全國(guó)心腦血管藥理學(xué)術(shù)會(huì)議，專題報(bào)告，寧波奉化，2017.10 14-17

58. 血小板活性負(fù)性調(diào)節(jié)機(jī)制，2016年全國(guó)心腦血管藥理學(xué)術(shù)會(huì)議學(xué)術(shù)報(bào)告，杭州，2016.10.14-16

59. 抗血小板中藥研究：現(xiàn)狀及展望，中國(guó)藥理學(xué)會(huì)第十三次全國(guó)學(xué)術(shù)大會(huì)專題報(bào)告，北京，2015.11.3-4

60. 血小板粘附聚集及其研究方法。受邀于華中師范大學(xué)化學(xué)學(xué)院學(xué)術(shù)報(bào)告，武漢，2015.11.24

61. Platelet promotes the proliferation of HepG2 cells through depressed expression of KLF6.2014醫(yī)學(xué)前沿論壇暨第六屆中俄醫(yī)藥國(guó)際學(xué)術(shù)論壇分組報(bào)告，哈爾濱，2014.7.1-3.

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