王維民

教授，博士生導(dǎo)師

海外高層次人才（青年千人）

湖北省百人計(jì)劃

湖北省杰出青年項(xiàng)目

華中科技大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫系

研究方向：細(xì)胞代謝和腫瘤免疫治療

個(gè)人簡(jiǎn)介：2006年畢業(yè)于蘭州大學(xué)并取得生物學(xué)學(xué)士學(xué)位，2011年畢業(yè)于北京協(xié)和醫(yī)學(xué)院基礎(chǔ)學(xué)院生物化學(xué)與分子生物學(xué)專業(yè)并取得博士學(xué)位，2011年至2019年期間先后在美國(guó)密歇根大學(xué)醫(yī)學(xué)院婦產(chǎn)科和外科進(jìn)行博士后研究。2019年入職華中科技大學(xué)基礎(chǔ)醫(yī)學(xué)院免疫學(xué)系任教授、博士生導(dǎo)師，現(xiàn)擔(dān)任基礎(chǔ)醫(yī)學(xué)院副院長(zhǎng)、免疫學(xué)系主任。入選國(guó)家“海外高層次人才（青年項(xiàng)目）”、湖北省“百人計(jì)劃”，兼任湖北省醫(yī)學(xué)生物免疫學(xué)基礎(chǔ)免疫專委會(huì)主委、中國(guó)免疫學(xué)會(huì)細(xì)胞治療專委會(huì)委員、中國(guó)細(xì)胞生物學(xué)會(huì)細(xì)胞死亡專委會(huì)委員。承擔(dān)科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃、國(guó)家自然科學(xué)基金和湖北省杰出青年基金等項(xiàng)目6項(xiàng)。在探索效應(yīng)性T細(xì)胞對(duì)腫瘤細(xì)胞代謝和死亡調(diào)控領(lǐng)域取得了一系列創(chuàng)新性研究成果，近年來(lái)主要代表性成果發(fā)表在Nature、Cell、Cancer Cell、Cell Metabolism和Nature Communications等國(guó)際主流學(xué)術(shù)期刊。目前主要從事細(xì)胞死亡、脂質(zhì)代謝及腫瘤免疫調(diào)控相關(guān)研究。

聯(lián)系方式：

武漢市航空路13號(hào)基礎(chǔ)醫(yī)學(xué)院2號(hào)樓1022

email:  weiminw@hust.edu.cn

代表性學(xué)術(shù)論文：

1. Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, Xue Y, Li Y, Chang Z, Li J, Chao T, Chen J, Cheng X, Gao X, Li X, Lu F, Chu Q, Wang W. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metabolism. 2024 Feb 8:S1550-4131(24)00012-3.

2. Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W. Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade. Nature Communications. 2023 Aug 8;14(1): 4758.

3. Liao P*, Wang W*, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gijón M, Shah YM, Zou W. CD8⁺ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022 Feb; S1535-6108(22)00036-8 (co-first)

4. Wang W*, Zou W*. Amino acid and their transporters in T cell immunity and cancer therapy. Molecular Cell. 2020 Nov; 80(3):384-395 (co-corresponding).

5. Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019 May;569(7755):270-274.

6. Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W. Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer. Cell. 2016 May 19; 165(5): 1092-105.

7. Wang W, Zou W, Liu R. Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Gynecol Oncol. 2018 Oct;151(1):1-3.

8. Wang W, Liu JR, Zou W. Immunotherapy in Ovarian Cancer. Surg Oncol Clin N Am. 2019 Jul; 28(3):447-464.

9. Wang W, Green M, Liu R, Lawrence T, Zou W. CD8+ T cells in Immunotherapy, Radiotherapy and Chemotherapy. Oncoimmunology, 2018. doi.org/10.1007/978-3-319-62431-0_3.

10. Wang W, Zhou J, Zhang Y, Liu S, Liu Y, Zheng D. HTLV-1 Tax-deregulated both autophagy pathway and c-FLIP expression contribute to the resistance against death receptor-mediated apoptosis. J Virol. 2014 Mar; 88(5):2786-98.

11. Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019 Dec; 9(12):1673-1685.

12. Maj T, Wang W, Wang W, Wei S, Zhao L, Linda Vatan L, Szeliga W, Liu R, Kryczek I, Zou W. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1 blockade in the tumor microenvironment. Nat Immunol, 2017 Dec;18(12):1332-1341.

13. Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW, Liu JR. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016 Mar 1; 122(5): 722-9.

14. Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015 Nov 12; 527(7577): 249-53