楊紅枚，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院人才引進(jìn)特聘教授、博士生導(dǎo)師。畢業(yè)于武漢大學(xué)病毒學(xué)專業(yè)；留學(xué)美國十年，先后在哈佛醫(yī)學(xué)院和美國生物醫(yī)藥公司從事病毒免疫、蛋白質(zhì)代謝和腫瘤生物學(xué)的研究及腫瘤治療藥物的研發(fā)。現(xiàn)任湖北省微生物學(xué)學(xué)會常務(wù)理事，微生物及免疫學(xué)會理事，國家自然科學(xué)基金委和教育部通訊評審專家等社會職務(wù)。共計(jì)發(fā)表科研論文30余篇，其中已被sci收錄近二十篇。

研究方向：

1.       感染與腫瘤

2.       丙型肝炎病毒致病機(jī)制及抗病毒藥物研發(fā)

3.       蛋白質(zhì)代謝與腫瘤惡病質(zhì)

主要論文：

1.      chen x, han w, ruan a, zhao y, xu z, lu x, yang h*, zhang x*. mir-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling epha2 expression. clinical cancer research. 2014  ( if：7.8，共同通訊作者)

2.      yang  h, chen x, wang x, li y, chen s, qian x, wang r, chen l, han w, ruan a, du q, olumi af, zhang x*. inhibition of pp2a activity confers a trail-sensitive phenotype during malignant transformation. mol cancer res, feb;12(2):217-27, 2014 ( if：4.6，第一作者)

3.      wang x. chen x, wang r, xiao p, xu z, chen l, han w, ruan a, yang h*, zhang x*. microrna-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. oncol rep,30(2): p. 643-50. 2013 ( if：2.2，共同通訊作者)

4.      hongmei yang, charles h. lin, gang ma, michael baffi and marc g. wathelet  transcriptional activity of interferon regulatory factor (irf)-3 depends on multiple protein-protein interactions. febs j. (eur. j. biochem.); 269(24): 6142-51, 2002 dec.

5.      hongmei yang, charles h. lin, gang ma, michael baffi and marc g. wathelet  interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/cbp coactivators. j biol chem.; 278(18): 15495-504, 2003 may 2.

6.      hongmei yang, gang ma, michael baffi and marc g. wathelet. mechanism for transcriptional synergy between interferon regulatory factor (irf)-3 and irf-7 in activation of the interferon-beta gene promoter. febs j. (eur. j. biochem.); 271(18): 3693-703, 2004 sep.

7.      hongmei yang, wei wei , michael menconi, and per-olof hasselgren.  dexamethasone-induced protein degradation in cultured myotubes is p300/hat-dependent. am i physiol regul integr comp physiol.; 292(1):r337-4, 2007 jan.

8.      hongmei yang, joshua mammen, micahel menconi, per-olof hasselgren. expression and activity of c/ebpbeta and delta are upregulated by dexamethasone in skeletal muscle. j cell physiol.; 204(1): 219-26, 2005 july.

9.      hongmei yang, mike menconin, per-olof hasselgren. dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with c/ebp beta in cultured myotubes. j cell biochem.; 94(5): 1058-67, 2005 apr 1.

10.  xiaoping zhang, liang zhang, hongmei yang, xu huang, hasan otu, towia a. libermann,, william c. dewolf, roya khosravi-far, aria f. olumi. c-fos as a proapoptotic agent in trail-induced apoptosis in prostate cancer cells. cancer res; 67(19): 9425-34,2007 oct 1.

11.  wei wei , hongmei yang , peirang cao , michael menconi, and per-olof hasselgren.  treatment of cultured myotubes with the proteasome inhibitor β-lactone increase the expression of the transcription factor c/ebp β. am j physiol cell physiol.; 292(1):c216-26, 2007 jan.

12.  wei wei , hongmei yang,  peirang cao , michael menconi, petkova v, hasselgren po. degradation of c/ebp β in cultured myotubes is calpain-dependent. j cell physiol.; 208(2): 386-98,2006 aug.

13.  hasselgren po, menconi mj, fareed mu, yang h, wei w, evenson a. novel aspects on the regulation of muscle wasting in sepsis. int j biochem cell biol. 2005 oct;37(10):2156-68. epub 2005 mar 13

14.  wei wei, fareed mu, evenson a, menconi mj, hongmei yang , petkova v, hasselgren po. sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. am j physiol regul integr comp physiol. 2005 mar; 288(3):r580-90.

15.  xiaoping zhang, tai-guang jin, hongmei yang, william c. dewolf, roya khosravi-far and aria f. olumi. persistent c-flip(l) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer. cancer res. 2004 oct 1; 64(19): 7086-91.

16.  menconi mj, wei w, hongmei yang, wray cj, hasselgren po. treatment of cultured myotubes with the calcium ionophore a23187 increases proteasome activity via a camk ii-caspase-calpain-dependent mechanism. surgery. 136(2): 135-42, 2004 aug.

主要著作：

楊紅枚參編，《病毒轉(zhuǎn)基因技術(shù)原理》。科學(xué)出版社，2014年。

科研項(xiàng)目：

1.       microrna-141調(diào)控hcv復(fù)制的機(jī)制研究，病毒學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放課題，2014-2016年；

2.       惡病質(zhì)肌肉萎縮中myostatin表達(dá)調(diào)控的機(jī)制研究，國家自然科學(xué)基金面上項(xiàng)目，2012-2015年；

3.       病毒激活因子（vaf）調(diào)控丙型肝炎病毒誘導(dǎo)的干擾素表達(dá)機(jī)制的研究，國家自然科學(xué)基金面上項(xiàng)目，2011-2013年。

4.       惡病質(zhì)肌肉萎縮中myostatin表達(dá)調(diào)控的機(jī)制研究，湖北省科技廳面上項(xiàng)目，2011-2012年；

5.       丙型肝炎病毒感染的肝細(xì)胞對trail敏感的機(jī)制研究，湖北省衛(wèi)生廳科研一般項(xiàng)目，2011-2012年。

6.       hcv感染的肝細(xì)胞對trail敏感的機(jī)制研究，華中科技大學(xué)自主創(chuàng)新研究基金資助項(xiàng)目，2010-2012年。