學(xué)習(xí)及科研經(jīng)歷

楊振華，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院教授、博士生導(dǎo)師。2012年于武漢大學(xué)生命科學(xué)學(xué)院獲得微生學(xué)專業(yè)博士學(xué)位，2012-2018年在美國(guó)阿拉巴馬州-伯明翰大學(xué)從事博士后/助理研究員工作，2018年11月作為課題組長(zhǎng)入職華中科技大學(xué)同濟(jì)基礎(chǔ)醫(yī)學(xué)院。

研究領(lǐng)域：

本實(shí)驗(yàn)室利用體內(nèi)和體外各種研究方案，對(duì)造血干細(xì)胞分化調(diào)控及血液腫瘤發(fā)生發(fā)展的分子機(jī)理進(jìn)行深入研究，并致力于在此基礎(chǔ)上的抗腫瘤轉(zhuǎn)化醫(yī)學(xué)研究。

聯(lián)系方式：

地址：同濟(jì)基礎(chǔ)醫(yī)學(xué)院2號(hào)樓1221室; 郵箱：zhenhua@hust.edu.cn

發(fā)表主要論文

1. Zhenhua Yang*· Hao Jiang*. A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells. Cellular and Molecular Life Sciences. 2020 https://doi.org/10.1007/s00018-020-03522-x

2. Zhenhua Yang*, Kushani Shah, Alireza Khodadadi-Jamayran, Hao Jiang*. Control of Hematopoietic Stem and Progenitor Cell Function Through Epigenetic Regulation of Energy Metabolism and Genome Integrity. Stem Cell Reports. 2019; 13, 61-75.

3. Zhenhua Yang^#, Kushani Shah^#, Theodore Busby, Robert Whitaker, Keith Giles, Alireza Khodadadi-Jamayran, Jing Hu, William Placzek, and Hao Jiang. Hijacking a key chromatin modulator creates targetable epigenetic vulnerability for Myc-driven cancer. Journal of Clinical Investigation. 2018;128, 3605-3618.

4. Zhenhua Yang, Kushani Shaha, Alireza Khodadadi-Jamayran, and Hao Jiang. Dpy30 Is Critical for Maintaining the Identity and Function of Adult Hematopoietic Stem Cells. The Journal of Experimental Medicine. 2016, doi/ 10.1084/jem.20160185.

5. Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Talat Nasim, Zefeng Wang, and Hao Jiang?. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nature Communications. 2016 Nov 8;7:13347. doi: 10.1038/ ncomms13347.

6. Zhenhua Yang, Jonathan Augustin, Jing Hu, and Hao Jiang. Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One. 2015, 10(12): 0145336.

7. Zhenhua Yang^#, Jonathan Augustin^#, Chenbei Chang, Jing Hu, Kushani Shah, Chia-Wei Chang, Tim Townes, and Hao Jiang. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 2014, 124(13): 2025-33.

8. Zhenhua Yang, Wu R, Li RW, Li L, Xiong Z, Zhao H, Guo D, Pan Z. Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections. Virus Res. 2012 Apr; 165(1):61-70.

9. Zhenhua Yang, Ling Li, Zishu Pan. Development of multiple ELISAs for the detection of antibodies against classical swine fever virus in pig sera. Virologica Sinica. 2012, 27(1):48-56.

10. Jing Qu, Zhenhua Yang,  Qi Zhang, Weiyong Liu, Youxing Li, Qiong Ding, Fang Liu, Yingle Liu, Zishu Pan, Biao He, Ying Zhu, Jianguo Wu, Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5′-untranslated region. FEBS. 2011, 585: 4002-4009.

11. Zhenhua Yang, Pan Tao, Siyu Zhou, Shuwen Wu, Zishu Pan. Expression of neuraminidase of H5N1 subtype avian influenza virus and production of polyclonal antibody. Journal of WuHan University. 2007, 53:481-484.

# Equal contribution; *Corresponding author