趙俊

工作單位： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院解剖系職位： 教授

電子郵箱: junzhao1981@hust.edu.cn

教育背景

1999-2004 中國科學(xué)技術(shù)大學(xué)化學(xué)系學(xué)士學(xué)位

2005-2006 美國印第安納大學(xué)-普渡大學(xué)印第安納波利斯分校 (Indiana University Purdue University Indianapolis) 生物醫(yī)學(xué)工程系碩士學(xué)位

2006-2009 美國普渡大學(xué)（Purdue University）生物醫(yī)學(xué)工程系哲學(xué)博士學(xué)位（導(dǎo)師：Professor Dong Xie）

工作經(jīng)歷

2009-2015 博士后，美國得克薩斯大學(xué)安德森癌癥中心（導(dǎo)師：李春教授）

2015-2019 講師， 美國得克薩斯大學(xué)安德森癌癥中心癌癥系統(tǒng)影像系

2019-至今 教授，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院解剖系

研究領(lǐng)域

納米醫(yī)學(xué)、介入治療、免疫治療、核醫(yī)學(xué)影像。主要研究方向：新型納米藥劑的開發(fā)與臨床轉(zhuǎn)化、腫瘤靶向藥物遞送、腫瘤微環(huán)境調(diào)節(jié)與療效增敏。

主要學(xué)術(shù)成果

本人的研究對象，是以胰腺癌為代表的具有高度耐藥性的實體腫瘤。針對胰腺癌纖 維化程度高、藥物遞送困難的特點，開發(fā)了一種新型高分子納米載體，在多個動物模型中 成功調(diào)節(jié)了腫瘤微環(huán)境，提高了藥物遞送效率，并顯著增強(qiáng)了放、化療與免疫治療的療效。成果已發(fā)表于 Journal of Controlled Release、Biomaterials 及 ACS Nano 等。該納米制劑已在中美兩國申請專利。此外，本人在國際上首先闡明，不可逆電穿孔介入療法（IRE）可 降低胰腺腫瘤微環(huán)境的免疫抑制性。利用 IRE 顯著提高了免疫檢查點抑制劑對胰腺癌的療效。成果將于近期發(fā)表于 Nature Communications。本人對腫瘤光熱治療及核醫(yī)學(xué)影像方向也有涉及， 成果發(fā)表于 Biomaterials，Applied Materials Today 、Nanoscale 等 。近五年內(nèi)以第一作者或共同第一作者身份發(fā)表學(xué)術(shù)論文 14 篇，涵蓋藥學(xué)、材料學(xué)和影像學(xué)等領(lǐng)域， 共計影響因子 98.3。已主持或參與學(xué)術(shù)基金 4 項。長期擔(dān)任 Advanced Functional Materials,

Acta Biomaterialia 等國際期刊審稿人。科研基金

1. 納米藥物緩釋調(diào)控腫瘤相關(guān)中性粒細(xì)胞以增強(qiáng)胰腺癌對不可逆電穿孔聯(lián)合 PD1 單抗治療響應(yīng)的研究，國家自然科學(xué)基金面上項目 82073400，2021.01-2024.12，55 萬元，主持

2. Improve Radiation Efficacy in Pancreatic Tumor using Nanoparticle-bound Radiosensitizer，安德森癌癥中心，4/1/2016-3/31/2017, $30,000，項目負(fù)責(zé)人

3. Determination of the efficacy of TIG1-targeted therapy using nanoparticle-delivered siRNA in inflammatory breast cancer, Morgan Welch 炎性乳腺癌研究計劃, 4/1/2016- 3/31/2017, $40,000，項目共同負(fù)責(zé)人

4. Targeted Delivery of Cyclopamine by Biodegradable Cross-Linked Polymeric Micelles for Radio-Chemotherapy of Pancreatic Cancer ， Skip Viragh 基金會， 2012-2018 ，

$1,400,000，合作研究人

5. Simultaneous Ablation of Tumor Cells and Tumor Stromal Cells to Enhance Antitumor against Pancreatic Ductal Adenocarcinoma，Gillson Longenbaugh 基金會，2016-2018，

$80,000，合作研究人

專利

Chun Li, Jun Zhao, Jason Fleming. Polymeric Drug Delivery Systems for Treatment of Disease, United States, 62/265,167, Pending

代表性 SCI 論文

1. Lincha, V. R. ?; Zhao, J. ?; Wen, X.; Xiong, C.; D, S. L. Chow; and Li, C., A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. International

Journal Pharmaceutics, 2021: p. 120523（影響因子 4.845）

2. Bao, G.; Tang, M.; Zhao, J.*; and Zhu, X.*, Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Res, 2021. 11(1): p. 6. DOI: 10.1186/s13550-021-

00750-5（影響因子 2.640）

3. Wu, Z. L. ?; Zhao, J. ?; and Xu, R., Recent advances in oral nano-antibiotics for bacterial infection therapy. Interntional Journal of Nanomedicine, 2020. 15: p. 9587-9610（影響因子 5.115）

4. Xiong, C.; Wen, Y.; Zhao, J.; Yin, D.; Xu, L.; Chelariu-Raicu, A.; Yao, C.; Leng, X.; Liu, J.; Chaudhari, RR.; Zhang, S.; Sood, AK.; Li, C. Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions. Scientific Reports, 2020. 10(1): p. 520（影響因子 3.998）

5. Lincha, V. R.; Hsiao, C.-H.; Zhao, J.; Li, C.; Chow, D. S.-L. Sensitive and rapid UHPLC– MS/MS assay for simultaneousquantifications of calcipotriol and paclitaxel in rat whole blood andplasma samples. Journal of Pharmaceutical and Biomedical Analysis, 2021, 192: 113685（影響因子 3.209） 

6. Cao, Q. ?; Wang, W. ?; Zhou, M. ?; Huang, Q.; Wen, X.; Zhao, J.; Shi, S.; Geng, K.; Li, F.; Hatakeyama, H.; Xu, C.; Piwnica-Worms, D.; Peng, W.; Zhou, D.; Sood, A. K.; and Li, C., Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine: Nanotechnology, Biology and Medicine, 2020. 25: p. 102169（影響因子 5.182）

7. Zhao, J.?; Wen, X.?; Li, T.; Shi, S.; Xiong, C.; Wang, Y. A.; and Li, C., Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 2020, 5(15): p. 8474-8482（共同一作，影響因子 2.87）

8. He, J. ?; Qiao, Y. ?; Zhang H. ?; Zhao, J. ?; Li, W.; Xie, T.; Zhong, D.; Wei, Q.; Hua, S.; Yu, Y.; Yao, K.; Santos, H.; Zhou M. Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials 2020, 234, 119763（共同一作，影響因子 10.274）

9. Zhong, D. ?; Zhao, J. ?; Li, Y; Qiao, Y.; Wei, Q.; He, J.; Xie, T.; Li, W., Zhou, M. Laser- triggered aggregated cubic α-Fe2O3@Au nanocomposites for magnetic resonance imaging and photothermal/enhanced radiation synergistic therapy. Biomaterials 2019, 210, 119369

（共同一作，影響因子 10.274）

10. Zhao, J.?; Wen, X. F.?; Tian, L.; Li, T.; Xu, C.; Wen, X. X.; Melancon, M. P., Gupta, S.; Shen, B.; Peng, W.; Li, C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Communications 2019, 10:899（影響因子 11.880）

11. Zhao, J.; Xiao, Z.; Li, T.; Chen, H.; Yuan, Y.; Wang, A. Y.; Hsiao, C. -H.; Chow, D. S.- L.; Overwijk, W.; Li, C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 2018, 12, 9881-9893.（影響因子13.709）

12. Zhou, B.?; Zhao, J.?; Qiao, Y.; Wei, Q.; He, J.; Li, W.; Zhong, D.; Ma, F.; Li, Y.; Zhou,

M. Simultaneous multimodal imaging and photothermal therapy via renal-clearable manganese-doped copper sulfide nanodots. Applied Materials Today 2018, 13, 285-297.

（共同一作，影響因子 8.013）

13. Zhao, J.; Wang, H.; Hsiao, C.-H.; Chow, D. S.-L.; Koay, E. J.; Kang, Y.; Wen, X.; Huang, Q.; Ma, Y.; Bankson, J. A.; et al. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 2018, 159, 215-228. （影響因子 10.273）

14. Zhao, J.; Koay, E. J.; Li, T.; Wen, X.; Li, C., A hindsight reflection on the clinical studies of poly (l‐glutamic acid)‐paclitaxel. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, 10 (3), e1497.（影響因子 6.35）

15. Wang, W.?; Zhao, J.?; Wen, X.; Lin, C. C.-J.; Li, J.; Huang, Q.; Yu, Y.; Lin, S.-Y.; Li, C., MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging 2017, 2017. （共同一作，影響因子 2.934） 

16. Zhao, J.; Zhou, M.; Li, C., Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnology 2016, 7 (9). (影響因子 4.22）

17. Zhou, M.; Zhao, J.; Tian, M.; Song, S.; Zhang, R.; Gupta, S.; Tan, D.; Shen, H.; Ferrari, M.; Li, C., Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 2015, 7 (46), 19438-19447.（影響因子 7.233）

18. Zhou, M.; Song, S.; Zhao, J.; Tian, M.; Li, C., Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy. Journal of Materials Chemistry B 2015, 3 (46), 8939-8948.（影響因子 4.543）

19. Zhao, J.; Wu, C.; Abbruzzese, J.; Hwang, R. F.; Li, C., Cyclopamine-loaded core-cross- linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Molecular Pharmaceutics 2015, 12 (6), 2093-2100. （影響因子 4.556）

20. Zhao, J.; Qiao, Y.; Zhou, M.; Wallace, M.; Gupta, S.; Li, C.; Melancon, M. P., Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles. ACS Macro Letters 2015, 4 (10), 1081-1084.（影響因子 6.131）

21. Zhao, J.; Lee, P.; J Wallace, M.; P Melancon, M., Gold nanoparticles in cancer therapy: efficacy, Biodistribution, and Toxicity. Current Pharmaceutical Design 2015, 21 (29), 4240-4251.（影響因子 2.757）

22. You, J.?; Zhao, J.?; Wen, X.; Wu, C.; Huang, Q.; Guan, F.; Wu, R.; Liang, D.; Li, C., Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of Controlled Release 2015, 202, 40-48. （共同一作，影響因子 7.877）

23. Zhao, J.; Wallace, M.; Melancon, M. P., Cancer theranostics with gold nanoshells.

Nanomedicine 2014, 9 (13), 2041-2057.（影響因子 5.005）

24. Zhao, J.; Vykoukal, J.; Abdelsalam, M.; Recio-Boiles, A.; Huang, Q.; Qiao, Y.; Singhana, B.; Wallace, M.; Avritscher, R.; Melancon, M. P., Stem cell-mediated delivery of SPIO- loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 2014, 25 (40), 405101.（影響因子 3.404）

25. Zhao, J.?; Song, S.?; Zhong, M.; Li, C., Dual-Modal Tumor Imaging via Long-Circulating

Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters 2011, 1 (1), 150-153. （影響因子 6.131)

國際會議報告邀請報告

1. Zhao J., Wu C., Li J., Hwang R.,Li C. “Cyclopamine-loaded Core-crosslinked Polymeric Micelles Enhanced Radiation Response in Pancreatic Cancer”. 10th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, 5/2014