劉蓉，女，三級(jí)教授，博士生導(dǎo)師，湖北省杰出青年基金獲得者，國(guó)際阿爾茨海默協(xié)會(huì)會(huì)刊《Journal of Alzheimer’s Disease》和國(guó)際神經(jīng)化學(xué)學(xué)會(huì)會(huì)刊《Journal of Neurochemistry》編委，中國(guó)神經(jīng)科學(xué)學(xué)會(huì)會(huì)刊《Neuroscience Bulletin》青年編委，教育部及湖北省神經(jīng)系統(tǒng)疾病重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)骨干，瑞典卡羅林斯卡醫(yī)學(xué)院、美國(guó)波士頓大學(xué)訪(fǎng)問(wèn)學(xué)者，國(guó)家自然科學(xué)基金委（NSFC）、英國(guó)醫(yī)學(xué)研究委員會(huì)（Medical Research Council）基金評(píng)審專(zhuān)家。多年從事神經(jīng)退行性疾病發(fā)病機(jī)制的研究，作為項(xiàng)目負(fù)責(zé)人獲多項(xiàng)國(guó)家自然科學(xué)基金資助，參與研究項(xiàng)目獲中華醫(yī)學(xué)科技二等獎(jiǎng)和教育部高等學(xué)校科學(xué)研究?jī)?yōu)秀成果獎(jiǎng)自然科學(xué)獎(jiǎng)一等獎(jiǎng)。對(duì)阿爾茨海默病及抑郁癥相關(guān)領(lǐng)域有較深厚的理論基礎(chǔ)和實(shí)踐經(jīng)驗(yàn)，以通訊作者在Nature系列刊物Molecular Psychiatry、 Cell Death & Disease, Cell系列刊物Cell reports、iScience等高水平國(guó)際期刊發(fā)表SCI論文多篇，通訊作者論文入選ESI高被引論文、F1000Prime推薦論文，發(fā)表論文H因子為30，被引用超過(guò)3300次。學(xué)生培養(yǎng)注重因材施教，目前已指導(dǎo)多名碩士、博士研究生，六名研究生獲得研究生國(guó)家獎(jiǎng)學(xué)金，多名研究生獲區(qū)級(jí)、校級(jí)優(yōu)秀研究生稱(chēng)號(hào)。獲華中科技大學(xué)2023年度三育人獎(jiǎng)。

聯(lián)系方式：

Email: Rong.liu@hust.edu.cn

Cell phone: 15327196073

基礎(chǔ)醫(yī)學(xué)院教學(xué)樓 823室

Researchgate: https://www.researchgate.net/profile/Rong_Liu19

ORCID: https://orcid.org/0000-0001-7477-6520

學(xué)術(shù)兼職：

國(guó)際雜志《Journal of Neurochemistry》執(zhí)行編委, 《Neuroscience bulletin》青年編委，《Science translational medicine》《Cell reports》,《Theranostics》,《Journal of clinical investigation》,《Molecular psychiatry》等二十多個(gè)國(guó)際學(xué)術(shù)雜志審稿人，國(guó)家自然科學(xué)基金生命科學(xué)部、醫(yī)學(xué)部評(píng)審專(zhuān)家，英國(guó)醫(yī)學(xué)研究委員會(huì)（Medical Research Council）基金評(píng)審專(zhuān)家，中國(guó)病理生理學(xué)會(huì)信號(hào)轉(zhuǎn)導(dǎo)專(zhuān)業(yè)委員會(huì)委員，湖北省微循環(huán)學(xué)會(huì)副理事長(zhǎng)，湖北省、武漢市病理生理學(xué)會(huì)常務(wù)理事。

研究方向：

1．老年性癡呆發(fā)病機(jī)制與防治。老年性癡呆又稱(chēng)阿爾茨海默病(AD)，隨全球人口老齡化發(fā)病率逐步增高，是老齡人口癡呆的最主要病因。目前AD發(fā)病機(jī)制不明，防治困難，本研究組主要聚焦于AD發(fā)病上游機(jī)制的研究，以期為其防治提供新靶點(diǎn)。近年來(lái)主要研究興趣領(lǐng)域如下：1) 環(huán)境因素如中樞神經(jīng)系統(tǒng)鋅穩(wěn)態(tài)異常、外周腸道微生物在AD發(fā)病中的作用和機(jī)制：研究組探討揭示腦內(nèi)微量元素鋅穩(wěn)態(tài)異常促進(jìn)AD樣tau病變的作用及其機(jī)制，發(fā)現(xiàn)干預(yù)鋅失衡可逆轉(zhuǎn)tau蛋白過(guò)度磷酸化和聚集；探討揭示外周幽門(mén)螺桿菌感染促進(jìn)腦內(nèi)AD樣病變的作用和機(jī)制。2) 蛋白磷酸酯酶2A(PP2A)的調(diào)節(jié)及其異常在神經(jīng)退變中的作用：PP2A活性抑制是AD腦內(nèi)tau蛋白過(guò)度磷酸化的關(guān)鍵促進(jìn)因素，研究組系統(tǒng)探討AD腦內(nèi)PP2A活性下調(diào)的上游機(jī)制及可能的干預(yù)措施，并通過(guò)廣泛的國(guó)際合作尋找候選治療化合物分子。

2. 抑郁癥發(fā)病機(jī)制與防治。隨著工業(yè)化進(jìn)展，抑郁癥（MDD）的全球發(fā)病率呈顯著增高趨勢(shì)，2018年數(shù)據(jù)指出全球MDD的年發(fā)病率為6%。抑郁癥發(fā)病機(jī)制不明，治療方法有限。研究組的主要研究興趣領(lǐng)域?yàn)樯窠?jīng)可塑性異常在抑郁癥中的作用和分子機(jī)制，陸續(xù)發(fā)現(xiàn)揭示了若干調(diào)控神經(jīng)發(fā)育和可塑性的關(guān)鍵分子在抑郁癥發(fā)病中的作用；并以此為干預(yù)靶點(diǎn)探索新的抑郁癥干預(yù)治療措施。

代表性論文（第一/通訊作者, *通訊作者）：

1. Zhang L, Gai Y, Liu Y, Meng D, Zeng Y, Luo Y, Zhang H, Wang Z, Yang M, Li Y, Liu Y, Lai Y, Yang J, Wu G, Chen Y, Zhu J, Liu S, Yu T, Zeng J, Wang J, Zhu D, Wang X*, Lan X*, Liu R*.Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clin Transl Med. 2024 Mar;14(3):e1623.

2. Hou Q, Hu W, Peterson L, Gilbert J, Liu R*, Man HY*. SIK1 Downregulates Synaptic AMPA Receptors and Contributes to Cognitive Defects in Alzheimer's Disease. Mol Neurobiol. 2024 May 10. doi: 10.1007/s12035-024-04177-6.

3. Wang Z, Zhang L, Yang J, Zeng Y, Su C, Yao M, Zhang H, Hu W, Liu Y, Lai Y, Wang X, Zeng J*, Liu R*. Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling. Aging (Albany NY). 2024 May 30;16(10):9168-9187

4. Meng D, Yang M, Zhang H, Zhang L, Song H, Liu Y, Zeng Y, Yang B, Wang X, Chen Y*, Liu R* Microglia activation mediates circadian rhythm disruption-induced cognitive impairment in mice. J Neuroimmunol. 2023 Jun 15;379:578102.

5. Hu WT, Liuyang ZY, Tian Y, Liang JW, Zhang XL, Zhang HL, Wang G, Huo Y, Shentu YP, Wang JZ, Wang XC, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization. EMBO Rep. 2022 Oct 28:e54911. doi:10.15252/embr.202254911.

6. Meng D, Yang M, Hu L, Liu T, Zhang H, Sun X, Wang X, Chen Y*, Jin Y*, Liu R*. Rifaximin protects against circadian rhythm disruption-induced cognitive impairment through preventing gut barrier damage and neuroinflammation. J Neurochem. 2022 Oct 3. doi: 10.1111/jnc.15701.

7. Hu W, Wang Z, Zhang H, Mahaman YAR, Huang F, Meng D, Zhou Y, Wang S, Jiang N, Xiong J, Westermarck J, Lu Y, Wang J, Wang X, Shentu Y, Liu R*. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. Neurotherapeutics. 2022 Mar 14. doi: 10.1007/s13311-022-01204-z.

8. Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul Razak MY, Hu W, Pan J, Wang X, Fan J, Li J, Liu R*, Shentu Y*. ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease. FASEB J. 2022 Mar;36(3):e22209.

9. Zhang H, Yang M, Wang X, Wei H, Du M, Wang M, Wang J, Chen Z, Peng C*, Liu R*. Zinc induces reactive astrogliosis through ERK dependent activation of Stat3 and promotes synaptic degeneration. J Neurochem. 2021 Dec;159(6):1016-1027.

10. Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R*, Shentu Y*. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020;34(12):16414-16431.

11. O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R*, Man HY*. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Aug 15;23(9):101465. doi: 10.1016/j.isci.2020.101465.

12. Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M*, Liu R*. Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models. Neurotherapeutics. 2020 Feb 24. doi: 10.1007/s13311-020-00841-6.

13. Shentu YP, Hu WT, Zhang Q, Huo Y, Liang JW, Liuyang ZY, Zhou H, Wei H, Ke D,Wang XC, Wang JZ, Man HY, Westermarck J, Liu R*. CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits. Neurobiol Aging. 2019;75:198-208.

14. Shentu YP*, Hu WT, Liang JW, Liuyang ZY, Wei H, Qun W, Wang XC, Wang JZ, Westermarck J, Liu R*. Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A. Curr Alzheimer Res. 2019;16(8):732-740.

15. Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease. Cell Rep. 2018 Jul 17;24(3):713-723. doi: 10.1016/j.celrep.2018.06.009.（F1000Prime推薦論文）

16. Tuo QZ, Liuyang ZY, Lei P, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R*. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870.

17. Liang JW, Fang ZY, Huang Y, Liuyang ZY, Zhang XL, Wang JL, Hui W, Wang JZ, Wang XC, Zeng J*, Liu R*. Application of Weighted Gene Co-Expression Network Analysis to Explore the Key Genes in Alzheimer's Disease. J Alzheimers Dis. 2018 Aug 16. doi: 10.3233/JAD-180400.

18. Zhou H, Guo Y, Li X, Liuyang ZY, Shentu YP, Jing XP, Liang JW, Zhou XW, Wang  XC, Wang JZ, Zeng J*, Liu R*. Long-term Helicobacter pylori Infection Does Not Induce Tauopathy and Memory Impairment in SD Rats. J Huazhong Univ Sci Technol［Med Sci］2017. 37(6):823-827.

19. Tuo QZ, Lei P*, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R*, Bush AI*. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry. 2017 Nov;22(11):1520-1530. doi:10.1038/mp.2017.171. （ESI高被引論文）

20. Qiu M, Shentu YP, Zeng J, Wang XC, Yan X, Zhou XW, Jing XP, Wang Q, Man HY, Wang JZ, Liu R*. Zinc mediates the neuronal activity-dependent anti-apoptotic effect. PLoS One. 2017;12(8):e0182150.

21. Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S, Wang XL, Cao FY, Wang XC, Wang JZ*, Liu R*. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell Death Dis. 2016 Nov 3;7(11):e2449.

22. Xiong Y, Luo DJ, Wang XL, Qiu M, Yang Y, Yan X, Wang JZ, Ye QF, Liu R*. Zinc binds to and directly inhibits protein phosphatase 2A in vitro. Neurosci Bull.2015 Jun;31(3):331-7.

23. Wang XL, Xiong Y, Yang Y, Tuo QZ, Wang XC, Chen R, Tian Q, Zhang ZP, Yan X, Yang ZY, Wang JZ*, Liu R*. A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aβ generation in cells. European Journal of Pharmacology. 2015, 754: 134-139

24. Wang XL, Zeng J, Yang Y, Xiong Y, Zhang ZH, Qiu M, Yan X, Sun XY, Tuo QZ, Liu R*, Wang JZ*. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. J Alzheimers Dis. 2015;43(1):153-65.

25. Wang XL, Zeng J, Feng J, Tian YT, Liu YJ, Qiu M, Yan X, Yang Y, Xiong Y, Zhang ZH, Wang Q, Wang JZ*, Liu R*. Helicobacter pylori filtrate impairs spacial learning and memory in rat and increases β-amyloid by enhancing expression of presenilin-2. Frontiers in Aging Neuroscience, 11 April 2014 | doi: 10.3389/fnagi.2014.00066

26. Yang Y, Jing XP, Zhang SP, Gu RX, Tang FX, Wang XL, Xiong Y, Qiu M, Sun XY, Ke D, Wang JZ, Liu R*. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PLoS One. 2013;8(1):e55384.

27. Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R*, Wang JZ*. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56.

28. Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R*, Wang JZ. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of PP2A. J Biol Chem.2012,287(14):11174-11182.

     

    主要科研項(xiàng)目：

29. 2021-2025 國(guó)家自然科學(xué)基金 550,000 RMB Tau病變活化小膠質(zhì)細(xì)胞時(shí)空特性及Tau蛋白乙酰化NLRP3導(dǎo)致小膠質(zhì)細(xì)胞活化的分子機(jī)制研究 項(xiàng)目負(fù)責(zé)人

30. 2020-2023國(guó)家自然科學(xué)基金 696,000 RMB DNA損傷導(dǎo)致細(xì)胞周期重入在神經(jīng)退變中的作用及分子機(jī)制研究 項(xiàng)目負(fù)責(zé)人

31. 2019-2021華中科技大學(xué)自主創(chuàng)新研究基金100,000 RMB  腸道菌外膜囊泡對(duì)神經(jīng)免疫的調(diào)節(jié)及其在神經(jīng)退變中的作用機(jī)制研究 項(xiàng)目負(fù)責(zé)人

32. 2018-2021 國(guó)家自然科學(xué)基金 700,000 RMB   CIP2A對(duì)星形膠質(zhì)細(xì)胞活化調(diào)控及其突觸損傷機(jī)制研究 項(xiàng)目負(fù)責(zé)人

33. 2017-2019  湖北省杰出青年基金200,000 RMB  CIP2A對(duì)星形膠質(zhì)細(xì)胞活化調(diào)控及其在阿爾茨海默病中的作用研究  項(xiàng)目負(fù)責(zé)人

34. 2015-2018 國(guó)家自然科學(xué)基金 700,000 RMB   CIP2A對(duì)蛋白磷酸酯酶2A的調(diào)節(jié)及其在阿爾茨海默病發(fā)病中的作用 項(xiàng)目負(fù)責(zé)人

35. 2013-2016  國(guó)家自然科學(xué)基金 700,000 RMB    Tau-PP2A-Src 復(fù)合體對(duì)NMDA 受體的異常調(diào)控在阿爾茨海默病發(fā)生中的作用 項(xiàng)目負(fù)責(zé)人

36. 2013-2016國(guó)家自然科學(xué)基金中加老年癡呆癥及相關(guān)病癥合作研究項(xiàng)目3,000,000 RMB      GSK-3 介導(dǎo)Aβ, tau 和胰島素相關(guān)阿爾茨海默樣突觸和膽堿能損傷的機(jī)制研究 第二完成人

37. 2012-2013 華中科技大學(xué)自主創(chuàng)新研究基金 50,000 RMB    CIP2A 對(duì)PP2A 的調(diào)節(jié)及其在阿爾茨海默病發(fā)病中的作用 項(xiàng)目負(fù)責(zé)人

38. 2010-2012 華中科技大學(xué)自主創(chuàng)新研究基金  70,000 RMB   鋅離子對(duì)蛋白磷酸酯酶2A的調(diào)節(jié)和機(jī)制 項(xiàng)目負(fù)責(zé)人

39. 2006-2008國(guó)家自然科學(xué)基金 240,000 RMB  蛋白磷酸脂酶2A的酪氨酸磷酸化修飾在AD發(fā)病中的作用 項(xiàng)目負(fù)責(zé)人

40. 2005-2006 瑞典Stiftelsen Gamla tj?narinnor基金   30,000 Kr  項(xiàng)目負(fù)責(zé)人

41. 2005-2006瑞典Gun Och Bertil Stohnes Stifielse基金   25,000 Kr   項(xiàng)目負(fù)責(zé)人