
李建莎,女,1975年生,副教師。1998年畢業(yè)于同濟(jì)醫(yī)科大學(xué),獲學(xué)士學(xué)位,并于同年留校于病理教研室任教。2004年6月獲得病理學(xué)碩士學(xué)位,2007年6月獲病理學(xué)博士學(xué)位。本科畢業(yè)留校后一直從事病理學(xué)教學(xué)、科研及外檢工作。自2001年開始研究survivin與惡性腫瘤發(fā)生發(fā)展及預(yù)后的關(guān)系,2004年博士期間參加國家基金資助課題“β-連環(huán)素/tcf信號在氣道上皮細(xì)胞鱗狀化生中的作用”(no.30200115)和“氣道上皮損傷修復(fù)中g(shù)sk3活性變化對細(xì)胞骨架的影響”(no.30470757)的研究工作。自2008年6月至2010年5月于美國emory大學(xué)兒科血液/腫瘤系周木想教授實(shí)驗室做博士后研究。作為課題負(fù)責(zé)人已完成國家自然科學(xué)基金青年基金“肺癌中糖原合酶激酶3β促進(jìn)survivin核內(nèi)轉(zhuǎn)位的作用及機(jī)制探討”(no. 30900545)一項及湖北省自然科學(xué)基金“gsk3及相關(guān)蛋白與survivin在肺癌發(fā)生中的作用研究”(2007aba130)一項。目前作為第三名參與國家自然科學(xué)基金重點(diǎn)項目“細(xì)胞外鈣感受器在肺動脈高壓發(fā)生發(fā)展中的作用及機(jī)制”(no:81330001,290.0萬,起止時間:2014.01-2018.12)。
近年發(fā)表的論文有:
1. xiong j, yang q, li j, zhou s. effects of mdm2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer. angiogenesis. 2014 jan;17(1):37-50.
2. tan r, li j (co-author), peng x, zhu l, cai l, wang t, su y, irani k, hu q. gapdh is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. cardiovasc res. 2013 oct 1;100(1):19-27.
3. li j, gu l, zhang h, liu t, tian d, zhou m, zhou s. berberine represses daxx gene transcription and induces cancer cell apoptosis. lab invest. 2013 mar;93(3):354-64.
4. song s, li j (co-author), zhu l, cai l, xu q, ling c, su y, hu q. irregular ca2+ oscillations regulate transcription via cumulative spike duration and spike amplitude. j biol chem. 2012 nov 23;287(48):40246-55.
5. zhang h, he j, li j, tian d, gu l, zhou m. methylation of rassf1a gene promoter is regulated by p53 and daxx. faseb j. 2013 jan;27(1):232-42.
6. zhang x, gu l, li j, shah n, he j, yang l, hu q, zhou m. degradation of mdm2 by the interaction between berberine and daxx leads to potent apoptosis in mdm2-overexpressing cancer cells. cancer res. 2010 dec 1;70(23):9895-904.
7. wang m, li n, li j, ma y, li d, qin l, wang x, wu r. involvement of p120 in lps-induced nf-kappab activation and il-8 production in human bronchial epithelial cells. toxicol lett. 2010 may 19;195(1):75-81.
8. tian d, zhu m, li j, ma y, wu r. cigarette smoke extract induces activation of beta-catenin/tcf signaling through inhibiting gsk3beta in human alveolar epithelial cell line. toxicol lett. 2009 may 22;187(1):58-62.
9. li j, xing m, zhu m, wang x, wang m, zhou s, li n, wu r, zhou m. glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization. cancer lett. 2008 dec 8;272(1):91-101.
10. li jian-sha, zhu min, tian dan, wu ren-liang. glycogen synthase kinase 3b induces cell cycle arrest in a cyclin d1-dependent manner in human lung adenocarcinoma cell line a549. acta physiologica sinica, 2007,59(2).
11. zhu m, tian d, li j, ma y, wang y, wu r. glycogen synthase kinase 3beta and beta-catenin are involved in the injury and repair of bronchial epithelial cells induced by scratching. exp mol pathol. 2007 aug;83(1):30-8.
12. 李建莎, 朱敏, 吳人亮*. 鋰對a549細(xì)胞增殖及細(xì)胞周期進(jìn)展的影響 華中科技大學(xué)學(xué)報(醫(yī)學(xué)版),2007,36(2).
13. li jiansha, wu huanming. expression of survivin in human non hodgkin’s lymphoma correlation with proliferation and angiogenesis. journal of huahzhong university of science and technology (health sciences; english version), 2006,26(5):504-507.
14.李建莎,吳人亮*。糖原合成酶激酶3的調(diào)節(jié)和功能 醫(yī)學(xué)分子生物學(xué)雜志,2006,3(5):383-386.