馬婧薇，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院免疫學(xué)系教授，博士研究生導(dǎo)師。2012年在華中科技大學(xué)獲得醫(yī)學(xué)免疫學(xué)博士學(xué)位。2012年至2015在中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所免疫學(xué)系黃波教授課題組從事博士后研究。2016年入職華中科技大學(xué)同濟(jì)醫(yī)學(xué)院免疫學(xué)系。2016年獲得中國免疫學(xué)會“第六屆青年學(xué)者獎”，2022年入選湖北省青年拔尖人才計劃，2024年入選“教育部長江學(xué)者獎勵計劃”青年學(xué)者，現(xiàn)為中國免疫學(xué)會女科學(xué)家工作委員會和中國抗癌協(xié)會腫瘤生物治療專業(yè)委員會委員。

研究方向主要為腫瘤免疫、細(xì)胞代謝調(diào)控和免疫衰老。主持國家自然基金委課題青年基金項目、面上項目、重大研究計劃、重大項目子課題等，近年來以第一/通訊作者在Nature Immunology、Nat Cell Biol、Nat Commun、Cell Res、Cell Mol Immunol、Immunity & Inflammation、Signal Transduct Target Ther等雜志發(fā)表SCI論文。作為團(tuán)隊主要成員研發(fā)“載藥囊泡治療腫瘤技術(shù)”，獲北京市科學(xué)技術(shù)獎自然科學(xué)獎一等獎，該項目已完成臨床轉(zhuǎn)化進(jìn)入應(yīng)用階段。

代表性研究成果：

1. Ma J#, Tang L#, Tan Y#, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K, Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8⁺ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Mar; 25(3):552-561.

2. Ma J, Tong S, Xiao J, Huang B*. Mannose: A game-changer for T cell immunotherapy. Cell Metab. 2025 Feb 4;37(2):313-315.

3. Wei K#, Tang L#, Zhang X#, Liu S, Tong S, Bian Y, Ma Y, Zhu T, Xiao J, Lin Q, Zhang R, Lv J, Zhang H, Tang K, Wu S, Ma J* & Huang B*. Lithium carbonate induces myofibroblast necroptosis to reverse pulmonary fibrosis. Immunity & Inflammation. 2025.1, 3.

4. Ma K#, Xu Y#, Cheng H#, Tang K#, Ma J#, Huang B*. T cell-based cancer immunotherapy: opportunities and challenges. Sci Bull (Beijing). 2025 Mar 31: S2095-9273(25)00337-8.

5. Tong S, Xiao J, Zhang X, Ma J*. Lithium: Emerging frontiers in metallopharmaceutical therapeutics. Molecular Immunology. 2025, 185: 39-52.

6. Ma J*, Tang L, Xiao J, Tang K, Zhang H, Huang B*. Burning lactic acid: a road to revitalizing antitumor immunity. Front Med. 2025 Mar 22.

7. Chen S#, Wang K#, Fan Z, Zhou T, Li R, Zhang B, Chen J, Chi J, Wei K, Liu J, Liu Z, Ma J*, Dong N* & Liu J*. Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages. Molecular Medicine. 2024, 30(1): 88.

8. Wei K#, Zhang H#, Yang S, Cui Y, Zhang B, Liu J,Tang L, Tan Y, Liu S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J*, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther. 2023 Jan 20;8(1):22.

9. Tang K#, Ma J#, Huang B*. Macrophages' M1 or M2 by tumor microparticles: lysosome makes decision. Cell Mol Immunol. 2022 Oct;19(10):1196-1197.

10. Ma J#, Tang K#, Zhang H#, Wei K, Huang B*. Characterization and Functional Analysis of Tumor-Derived Microparticles. Curr Protoc. 2021 Jun;1(6):e144.

11. Ma J, Zhang H, Tang K, Huang B*. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020 Sep 25.

12. Ma J#, Wei K#, Liu J#, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B*. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.

13. Zhang H#, Tang K#, Ma J#, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B*. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

14. Ma J#, Wei K#, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B*. Mechanisms by which dendritic cells present tumor microparticle antigens to CD8+ T cells. Cancer Immunol Res. 2018 Jul 17.

15. Ma J#, Zhang Y#, Tang K, Yin X, Zhang H, Li Y, Zhang S, Hu Z, Wang N, Yang X, Huang B*. Delivery of chemotherapeutic drug by tumor cell-derived microparticles reverses drug resistance of tumor-repopulating cells. Cell Res. 2016 Jun; 26(6):713-27.

16. Jin X#, Ma J#, Liang X#, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B*. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 113:93-104. 2017.

17. Ma J#, Cai W#, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Shen G*, Huang B*. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin α(M)β? to tumor cells. J Immunol. 191:3453-61. 2013.

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