聯(lián)系方式：武漢市漢口航空路13#，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)2號(hào)樓1125室，華中科技大學(xué)腦研究所，華中科技大學(xué)神經(jīng)生物學(xué)系

工作背景：

2015.03-至今   副教授，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院，基礎(chǔ)醫(yī)學(xué)院神經(jīng)生物學(xué)系；

2019.09-2021.09 高級(jí)訪問(wèn)學(xué)者，美國(guó)華盛頓大學(xué)醫(yī)學(xué)院，疼痛中心與麻醉學(xué)系；

2016.12-2017.12掛職，科技部中國(guó)生物技術(shù)發(fā)展中心，醫(yī)藥處

2011.08-2015.03 博士后，華中科技大學(xué)基礎(chǔ)醫(yī)學(xué)博士后流動(dòng)站，合作導(dǎo)師為魯友明教授；

2009.09-2010.12 訪問(wèn)科學(xué)家，荷蘭神經(jīng)科學(xué)研究所（NIN）/阿姆斯特丹大學(xué)醫(yī)學(xué)中心(AMC)，研究方向?yàn)橄虑鹉X參與外周能量代謝調(diào)控的神經(jīng)機(jī)制，合作導(dǎo)師為著名的神經(jīng)科學(xué)家Dick Swaab教授與Andries Kalsbeek教授。

教育背景：

2007.09-2011.06 博士學(xué)位，華中科技大學(xué)同濟(jì)醫(yī)學(xué)院神經(jīng)生物學(xué)系攻讀細(xì)胞與分子神經(jīng)生物學(xué)專業(yè)博士，研究方向?yàn)樘弁吹募?xì)胞與分子神經(jīng)生物學(xué)機(jī)制，導(dǎo)師為施靜教授；

2004.09-2007.07 碩士學(xué)位,華中科技大學(xué)同濟(jì)醫(yī)學(xué)院攻讀神經(jīng)生物學(xué)系碩

士，研究方向?yàn)檠装Y性疼痛的細(xì)胞與分子機(jī)制；

1998.09-2003.07 醫(yī)學(xué)學(xué)士學(xué)位，咸寧醫(yī)學(xué)院攻讀臨床醫(yī)學(xué)系本科；

(1) Ke, X, Deng, MF, Wu, Z, Yu, H, Yu, D, Li, H, Lu, Y, Shu, K, Pei, L*. miR?34b?3p Inhibition of eIF4E Causes Post?stroke Depression in Adult Mice. Neurosci. Bull. 2022 July 8 (Online); https://doi.org/10.1007/s12264-022-00898-7. (Co-corresponding author)

(2) Zhang, YF, Ma, SH, Ke, X, Yi, Y, Yu, HY, Yu, D, Li, Q, Shang, Y, Lu, YM, Pei, L*. The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons. Cell Biosci. 2021 Aug 26;11(1):167. (corresponding author)

(3) Su, TF, Yan, Y, Li, Q, Ye, JC*, Pei, L*. Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia. Front Psychiatry. 2021 Oct 22;12:734837. (Co-corresponding author)

(4) Su, TF, Pei, L*. Acupuncture and oxytocinergic system: The promising treatment for autism. Transl Neurosci. 2021 Feb 16;12(1):96-102. (corresponding author)

(5) Ma, XY, Xiao, WC, Li, H, Pang, P, Xue, FX, Wan, L, Pei, L*, Yan, HH*.Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model. Brain Behav Immun. 2021 Jul;95:68-83. (Co-corresponding author)

(6) Wang S, Chen D, Yu J, Wang X, Li Q, Lv F, Shen H, Pei L*. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Exp Neurol. 2020 Jul;329:113303. (corresponding author)

(7)Cai Y, Zhang Y, Ke X, Guo Y, Yao C, Tang N, Pang P, Xie G, Fang L, Zhang Z, Li J, Fan Y, He X, Wen R, Pei L*, Lu Y*. Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke. Front Genet. 2019 Sep 24;10:814. doi: 10.3389/fgene.2019.00814. (corresponding author)

(8)Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, Afewerky HK, Zhang X, Pei L*, Lu Y*. Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. Mol Neurobiol. 2019 May;56(5):3368-3379.(corresponding author)

(9)Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L*, Feng D*. The role of NLRP3 inflammasome in stroke and central poststroke pain. Medicine (Baltimore). 2018 Aug;97(33):e11861.(corresponding author)

(10)Xiong W, Wu Y, Xian W, Song L, Hu L, Pan S, Liu M, Yao S, Pei L*, Shang Y*. DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells. J Neurol Sci. 2018 Apr 15;387:210-219. (corresponding author)

(11)Song L*, Pei L*, Hu L, Pan S, Xiong W, Liu M, Wu Y, Shang Y, Yao S. Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice. Sci Rep. 2018 Jul 2;8(1):9930.

(12)Chen LM, Zhu MX, Zhang YF, Ma SH, Yi Y, Xia LX, Wu Y, Pei L*. A 58-Year

Old Male with Cognitive Deteriorations Caused by Septum Pellucidum Cyst: A Case Report. Front Aging Neurosci. 2017 Sep 13;9:299. doi: 10.3389/fnagi.2017.00299. eCollection 2017. (corresponding author)

(13)Jin HJ*, Pei L*, Li YN*, Zheng H, et al. Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression.Sci Rep.2017Nov2;7(1):14926. doi: 10.1038/s41598-017-13929-5.

(14)Song L*, Pei L*, Yao S, Wu Y, Shang Y. NLRP3 Inflammasome in Neurological  

Diseases, from Functions to Therapies. Front Cell Neurosci. 2017 Mar 9;11:63. (Co-first author)

(15) Tang N, Wu J, Zhu H, Yan H, Guo Y, Cai Y, Yan H, Shi Y, Shu S, Pei L*, Lu Y*. Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0562-y. (corresponding author).

(16)Lei Pei, Shan Wang, Jin Huijuan, et al. A Novel Mechanism of Spine Damages in stroke via DAPK1 and Tau. Cereb Cortex. 2015 Nov;25(11):4559-71.

(17)H Jin*, L Pei*, X Shu*, X Yang, T Yan, Y Wu, Na Wei, Honglin Yan, Shan Wang, Chengye Yao, Dan Liu, Qing Tian, Lin Wang, Youming Lu. Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging. Molecular Neurobiology, 2016 Mar;53(2):851-66. (Co-first author)

(18)Xiaoxi Wang*, Lei Pei*, Honglin Yan*, Zhongping Wang, Na Wei, Shan Wang, Xin Yang, Qing Tian, and Youming Lu. Intervention of DAPK1-p53 Interaction Exerts the Therapeutic Effects against Stroke. Stroke, 2014 Oct;45(10):3089-91 (Co-first author)

(19)Lei Pei, You Shang, Huijuan Jin, Shan Wang, Na Wei, Honglin Yan, Yan Wu,  

Chengye Yao, Xiaoxi Wang, Ling-Qiang Zhu, and Youming Lu. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. The Journal of Neuroscience, 2014, 34(19):6546–6556.

(20)Lizhao Wang, Dan Feng, Huanhuan Yan, Zhongping Wang, Lei Pei*. The Comparative Analysis of P2X1, P2X2, P2X3 AND P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons. PLoS ONE 9(05): e96699, doi:10.1371/journal.pone.0096699 (corresponding author).

(21)L Chen, F Lv, L Pei*. Annexin 1: a glucocorticoid-inducible protein that modulates inflammatory pain. European Journal of Pain, 18 (2014) 338–347 (corresponding author).

(22)L Chen, M Jiang, L Pei*. Comparison of Three Method s of Drug Delivery in the

Rat Lumbar Spinal Subarachnoid Space. THE ANATOMICAL RECORD 2012, 295:1212–1220 (corresponding author).

(23)L Pei, J Zhang, F Zhao, T Su, H Wei, J Tian, M Li, J Shi. Annexin 1 exerts anti-nociceptive effects through formyl-peptide-receptor-like 1 in rat dorsal root ganglion after peripheral inflammatory pain. British Journal of Anaesthesia 2011, 107(6): 948-958.

(24)L Pei, C Lin, J Dai, G Yin. Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion, Neuroscience Bulletin 2007, 23(2): 92-100.

Co-author Publications

(1)Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ, Lu Y. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250.

(2)Tuo QZ, Liuyang ZY, Pei L, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870.

(3)Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease. Mol Psychiatry. 2018 Feb;23(2):167.

(4)Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. doi: 10.1038/s41467-017-01943-0.

(5)Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM.Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Mol Neurobiol. 2016 Apr;53(3):2054-2064.

(6)Zhang T, Pang P, Fang Z, Guo Y, Li H, Li X, Tian T, Yang X, Chen W, Shu S, Tang N, Wu J, Zhu H, Pei L, Liu D, Tian Q, Wang J, Wang L, Zhu LQ, Lu Y. Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer's Disease Via APP Translation. Mol Neurobiol. 2017 Nov 13. doi: 10.1007/s12035-017-0820-z.

(7)Wang S, Shi X, Li H, Pang P, Pei L, Shen H, Lu Y. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Mol Neurobiol. 2017 Aug;54(6):4716-4722.

(8) Yan H, Pang P, Chen W, Zhu H, Henok K A, Li H, Wu Z, Ke X, Wu J, Zhang T, Pan K, Pei L, Han Y, Lu Y. The Lesion Analysis of Cholinergic Neurons in 5XFAD Mouse Model in the Three-Dimensional Level of Whole Brain. Mol Neurobiol. 2017 Jul 7. doi: 10.1007/s12035-017-0672-6.

(9) Shu S, Zhu H, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ, Lu Y. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852.

(10) Xian W, Wu Y, Xiong W, Li L, Li T, Pan S, Song L, Hu L, Pei L, Yao S, Shang Y. The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response. Biochem Biophys Res Commun. 2016 Mar 25;472(1):175-81.

(11) Li L, Wu Y, Wang Y, Wu J, Song L, Xian W, Yuan S, Pei L, Shang Y. Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells. J Neuroinflammation. 2014 Apr 5;11:72. doi: 10.1186/1742-2094-11-72.

(12)K Zhao, R Wen, X Wang, Pei L, Y Yang, Y Shang, N Bazan, L Zhu, Q Tian, and Y Lu. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. The Journal of Neuroscience, 2013, 33(20): 8861-8865.

(13)Y Yang, X Shu, D Liu, Y Shang, Y Wu, Pei L, X Xu, Q Tian, K Qian, Y Wang, R S. Petralia, W Tu, L Zhu, J Wang, Y Lu. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron 2012, 73(4):774-778.

(14)E Bruinstroop, Pei L, M T Ackermans, E Foppen, A J Borgers, J Kwakkel, A Alkemade, E Fliers, A Kalsbeek. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system, Diabetes 2012, 61(5):1043-1050.

(15) A Alkemade, C Yi, Pei L, M Harakalova, D F Swaab, S E la Fleur, E Fliers, A Kalsbeek. AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in MSH are related to type 2 diabetes, The Journal of Clinical Endocrinology & Metabolism 2012, 97(6):E925-33.

(16) J Zhang, F Zhao, Y Zhao, J Wang, L Pei, N Sun, J Shi. Hypoxia induces an increase in intracellular magnesium via TRPM7 channels in rat hippocampal neurons in vitro, The Journal of biological chemistry 2011, 286(23):0194-20207.

(17) TF Su, YQ Zhao, LH Zhang, M Peng, CH Wu, L Pei, B Tian, J Zhang, J Shi, HL Pan, M Li Electroacupuncture Reduces the Expression of Proinflammatory Cytokines in Inflamed Skin Tissues through Activation of Cannabinoid CB2 Receptors, European journal of pain 2011, 7(1): 98.

(18) J Zhang, L Chen, T Su, F Cao, X Meng, L Pei, J Shi, HL Pan, M Li. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats, The Journal of Pain 2010, 11(12), 1250-1258.

(19) W Fu, J Chen, Y Cai, Y Lei, L Chen, L Pei, D Zhou, X Liang, J Ruan. Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica Ching, Journal of Ethnopharmacology 2010, 130 (3): 521-528.

(20) H Liu, Z Li, M Yang, X Tian, L Pei, C Li. Sensory innervation of the anterior eye segment in rats: a retrograde tracing study. FRONTIERS OF MEDICINE IN CHINA 2009, 3 (3): 352-356.

(21) Jiang Q, Wang L, Guan Y, Xu H, Niu Y, Han L, Wei YP, Lin L, Chu J, Wang Q, Yang Y, L Pei, Wang JZ, Tian Q. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiol Aging. 2014 Jun;35(6):1352-63.

專利

(1) 張玉芬; 馬瑟惠; 柯霄; 余鴻雁; 余點(diǎn); 尚游; 裴磊; 魯友明 ; 一種大鼠腦內(nèi)自由給藥及采血裝置,2020-05-15, 中國(guó), ZL 2019 2 0852792.3

(2)旺姍,裴磊,顏歡歡,郭豫,李浩,唐娜,龐培,魯友明; 一種小分子多肽、其應(yīng)用及產(chǎn)品. 2015.04.08, CN201410734580.7

(3)李熳,潘曉莉,王俊俊,劉雙喜,張力,宋元龍,郭樂(lè)江,裴磊. 一種臨床用肌電測(cè)痛裝置，2015.7.1，中國(guó)，ZL 2014 2 0865547.3；

(4)魯友明,裴磊,朱鈴強(qiáng),徐傳瑞. 小分子多肽TAT-p53DM及其在制備治療或預(yù)防缺血性卒中藥物中的應(yīng)用,2015.10.28,中國(guó)，ZL 2014 1 0141844.8;

(5)裴磊, 施靜. 簡(jiǎn)易熱機(jī)械兩用測(cè)痛儀（ZL 2009 20154972.0 CN201533832U）

主持科研項(xiàng)目

（1）華中科技大學(xué)自主創(chuàng)新研究基金項(xiàng)目《缺血性卒中后DAPK1通過(guò)Caytaxin介導(dǎo)突觸前損傷的機(jī)制研究》（5萬(wàn)元）（已結(jié)題）

（2）中荷合作項(xiàng)目《下丘腦參與外周能量代謝調(diào)控的神經(jīng)機(jī)制（09CDP022）研究》（1.95萬(wàn)歐元）（已結(jié)題）

（4）中國(guó)博士后科學(xué)基金面上項(xiàng)目一等資助（Annexin1-FPR2/ALX通路抑制TRPV1作用機(jī)制研究）（2013M530345）(8萬(wàn)元) （已結(jié)題）

（5）中國(guó)博士后科學(xué)基金面上項(xiàng)目一等資助（DAPK1-Tau相互作用介導(dǎo)突觸損傷的機(jī)制研究） （2013M540583）(8萬(wàn)元) （已結(jié)題）

（6）國(guó)家自然科學(xué)基金青年研究項(xiàng)目<Annexin1 調(diào)節(jié)瞬時(shí)感受器電位香草素受體1 敏感性介導(dǎo)抗炎癥痛的機(jī)制研究>（81200863）（23萬(wàn)元）（已結(jié)題）

（7）國(guó)家自然科學(xué)基金面上研究項(xiàng)目<死亡相關(guān)蛋白激酶1介導(dǎo)皮層丘腦環(huán)路損傷引起卒中后疼痛的機(jī)制研究>（81571078）（57萬(wàn)元）

（8）國(guó)家自然科學(xué)基金面上研究項(xiàng)目<死亡相關(guān)蛋白激酶1損傷海馬前額葉皮層環(huán)路介導(dǎo)卒中后抑郁的機(jī)制研究>（81870932）（56萬(wàn)元）

參與學(xué)術(shù)活動(dòng) （會(huì)議）

(1) 中英學(xué)術(shù)大講堂（一）

(2) 2020科學(xué)編輯理事會(huì)年會(huì) （2020 CSE Virtual Annual Meeting (CSE2020)），美國(guó)圣路易斯華盛頓大學(xué)醫(yī)學(xué)院（WUSTL），2020年5月4日，How to survive and thrive in the research environment and system in China: an experience of a medical scientist.口頭報(bào)告。

(3)第38屆日本神經(jīng)科學(xué)年會(huì) (the 38th Annual Meeting of the Japanese Neuroscience Society)，日本神戶國(guó)際會(huì)議中心，2015年 7月28-31日，Cerebrovascular Disease and Ischemia Session, 2007-2-3(17:00),口頭報(bào)告。

獲獎(jiǎng)情況：

2014年 IBRO國(guó)際腦研究組織 Travel Grant

2015年 德國(guó)神經(jīng)科學(xué)學(xué)會(huì)GNS Travel Grant (Stipend for the 11th G?ttingen Meeting of the German Neuroscience Society 2015)

2015年 第38屆日本神經(jīng)科學(xué)年會(huì)Travel Awards (Travel Awards for the 38th Annual Meeting of the JNS)

2015年 中國(guó)神經(jīng)科學(xué)學(xué)會(huì)賽諾菲優(yōu)秀會(huì)議論文獎(jiǎng)

2016年 湖北省科學(xué)協(xié)會(huì)第16屆自然科學(xué)優(yōu)秀論文一等獎(jiǎng)