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彭挺

作者: 時(shí)間:2024-12-10 點(diǎn)擊量:

 

 

彭挺,博士,碩士生導(dǎo)師,華中科技大學(xué)同濟(jì)醫(yī)學(xué)院組織學(xué)與胚胎學(xué)系副教授,華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬中學(xué)科學(xué)副校長(zhǎng),基礎(chǔ)醫(yī)學(xué)院形態(tài)學(xué)實(shí)驗(yàn)中心副主任。武漢大學(xué)生命科學(xué)院本科,學(xué)士;華中科技大學(xué)同濟(jì)醫(yī)學(xué)院研究生,碩士、博士。湖北省解剖學(xué)會(huì)理事,湖北省細(xì)胞生物學(xué)會(huì)理事,中國(guó)解剖協(xié)會(huì)發(fā)育生物學(xué)分會(huì)青年委員。湖北省名師工作室團(tuán)隊(duì)成員,從事組織胚胎學(xué)、發(fā)育生物學(xué)、細(xì)胞生物學(xué)教學(xué)工作,國(guó)家級(jí)線下一流課程《組織學(xué)與胚胎學(xué)》,人衛(wèi)慕課《組織學(xué)與胚胎學(xué)》、國(guó)家精品資源共享課程、國(guó)家精品課程、國(guó)家雙語(yǔ)教學(xué)示范課程建設(shè)項(xiàng)目的主要成員和視頻主講教師。國(guó)家十二五規(guī)劃教材《組織學(xué)與胚胎學(xué)第3版》編委,全國(guó)高等學(xué)校八年制及“5+3”一體化臨床醫(yī)學(xué)專(zhuān)業(yè)第四輪規(guī)劃教材《組織學(xué)與胚胎學(xué)第四版》數(shù)字編委。《中國(guó)組織化學(xué)與細(xì)胞化學(xué)雜志》編委,圖像編輯;《解剖學(xué)報(bào)》青年編委。

主要研究方向:神經(jīng)退行性疾病發(fā)病機(jī)制、神經(jīng)發(fā)育,及腫瘤細(xì)胞生物學(xué)。重點(diǎn)關(guān)注亨廷頓舞蹈病的發(fā)病機(jī)制和治療,在突變亨廷頓蛋白異常聚集、泛素化修飾降解、細(xì)胞毒性產(chǎn)生等方面取得重要進(jìn)展。

曾獲首屆華中科技大學(xué)十大魅力教師,華中科技大學(xué)青年教師教學(xué)競(jìng)賽一等獎(jiǎng),湖北省首屆青年教師教學(xué)競(jìng)賽二等獎(jiǎng),指導(dǎo)學(xué)生獲首屆和第三屆全國(guó)大學(xué)生基礎(chǔ)醫(yī)學(xué)實(shí)驗(yàn)設(shè)計(jì)大賽一等獎(jiǎng)。主持國(guó)家自然科學(xué)基金面上項(xiàng)目1項(xiàng),參與4項(xiàng);主持華中科技大學(xué)自主創(chuàng)新研究基金2項(xiàng),重點(diǎn)項(xiàng)目1項(xiàng),省級(jí)科研教改項(xiàng)目2項(xiàng)。發(fā)表SCI論文13篇,其中以通訊作者身份發(fā)表5篇。

主要論文:

  1. Liu, J., Tan, X., Li, L., Cao, L., Zhou, Y., Li, H., and Peng, T. (2024) Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage. Cell death discovery 10, 130

  2. Xiang, D. D., Liu, J. T., Zhong, Z. B., Xiong, Y., Kong, H. Y., Yu, H. J., Peng, T., and Huang, J. Q. (2023) MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition. Curr Med Sci 43, 456-468

  3. Du, A., Li, L., Jiao, Z., Zhu, G., Peng, T., and Li, H. (2021) Protein expression pattern of calcium-responsive transactivator in early postnatal and adult testes. Histochemistry and cell biology 155, 491-502

  4. Zhu, G., Peng, T., Peng, C., and Li, H. (2019) Chronic lead exposure decreases the expression of Huntingtin-associated protein 1 (HAP1) through Repressor element-1 silencing transcription (REST). Toxicol Lett 306, 1-10

  5. Luo, H., Cao, L., Liang, X., Du, A., Peng, T., and Li, H. (2018) Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones. Mol Neurobiol 55, 7652-7668

  6. Niu, L., Ye, C., Sun, Y., Peng, T., Yang, S., Wang, W., and Li, H. (2018) Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease. Cell & bioscience 8, 41

  7. Liu, X., Peng, T., and Li, H. (2018) Using Huntingtin Knock-In Minipigs to Fill the Gap Between Mouse Models and Patients with Huntington's Disease. Neurosci Bull 34, 870-872

  8. Lin, L., Jin, Z., Tan, H., Xu, Q., Peng, T., and Li, H. (2016) Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. Brain Res 1643, 103-112

  9. Fang, F., Peng, T., Yang, S., Wang, W., Zhang, Y., and Li, H. (2016) Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT. Int J Dev Neurosci 52, 66-74

  10. Jiang, Y., Lv, H., Liao, M., Xu, X., Huang, S., Tan, H., Peng, T., Zhang, Y., and Li, H. (2012) GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins. Neurosci Lett 516, 182-187

  11. Wang, Z., Peng, T., Wu, H., He, J., and Li, H. (2015) HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic beta cells. Histochemistry and cell biology 144, 39-48

  12. Zhang, T., Dong, K., Liang, W., Xu, D., Xia, H., Geng, J., Najafov, A., Liu, M., Li, Y., Han, X., Xiao, J., Jin, Z., Peng, T., Gao, Y., Cai, Y., Qi, C., Zhang, Q., Sun, A., Lipinski, M., Zhu, H., Xiong, Y., Pandolfi, P. P., Li, H., Yu, Q., and Yuan, J. (2015) G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife 4, e06734

  13. Liao, M., Chen, X., Han, J., Yang, S., Peng, T., and Li, H. (2010) Selective expression of Huntingtin-associated protein 1 in beta-cells of the rat pancreatic islets. J Histochem Cytochem 58, 255-263

 

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