宋質(zhì)銀，華中科技大學(xué)基礎(chǔ)醫(yī)學(xué)院教授，博士生導(dǎo)師。1999年畢業(yè)于安徽大學(xué)，獲學(xué)士學(xué)位。2005年畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué)，獲博士學(xué)位。2005－2010年在美國(guó)加州理工學(xué)院（Caltech）從事博士后/研究助理。“國(guó)家杰出青年基金”獲得者，擔(dān)任中國(guó)生物物理學(xué)會(huì)線粒體生物學(xué)分會(huì)副會(huì)長(zhǎng)、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)細(xì)胞器分會(huì)委員、湖北省細(xì)胞生物學(xué)學(xué)會(huì)理事。主要研究線粒體動(dòng)態(tài)調(diào)控和質(zhì)量控制的分子機(jī)制及功能，開(kāi)發(fā)線粒體、溶酶體、內(nèi)質(zhì)網(wǎng)等研究新技術(shù)新方法，研究線粒體及相關(guān)細(xì)胞器在肝臟疾病、心血管疾病、腫瘤及神經(jīng)退行性疾病等發(fā)生發(fā)展中作用及分子機(jī)制，探索線粒體相關(guān)疾病干預(yù)及診治的新靶點(diǎn)和新策略。

電子郵箱：songzy@hust.edu.cn

主要研究方向

1.線粒體動(dòng)態(tài)調(diào)控和質(zhì)量控制

2.線粒體及相關(guān)細(xì)胞器生理病理功能

3.腫瘤代謝

近5年主持或參加的科研項(xiàng)目

1.國(guó)家自然科學(xué)基金“細(xì)胞器互作網(wǎng)絡(luò)及其功能研究”重大研究計(jì)劃集成項(xiàng)目, 92354304、“線粒體細(xì)胞器互作網(wǎng)絡(luò)調(diào)控機(jī)制及功能”、2024/01-2025/12，475萬(wàn)元、在研、主持

2.國(guó)家杰出青年科學(xué)基金, 32125011、“線粒體動(dòng)態(tài)調(diào)控與質(zhì)量控制”、2022/01-2026/12，400萬(wàn)元、在研、主持

3.國(guó)家自然科學(xué)基金面上項(xiàng)目, 31970711、“線粒體蛋白酶OMA1調(diào)控結(jié)直腸癌細(xì)胞能量代謝研究”、2020/01-2023/12，58萬(wàn)元、已結(jié)題、主持

4.科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃，2018YFA0800700、“應(yīng)激對(duì)組織器官代謝穩(wěn)態(tài)和發(fā)育的調(diào)控作用與機(jī)制”、2019/07-2024/06，140萬(wàn)（個(gè)人分配經(jīng)費(fèi)）（2311萬(wàn)總經(jīng)費(fèi)），在研、骨干

5.國(guó)家自然科學(xué)基金“細(xì)胞器互作網(wǎng)絡(luò)及其功能研究”重大研究計(jì)劃培育項(xiàng)目, 91854107、“線粒體內(nèi)外膜接觸調(diào)控線粒體與內(nèi)質(zhì)網(wǎng)互作研究”、2019/01-2021/12，96萬(wàn)元、已結(jié)題、主持

6.國(guó)家自然科學(xué)基金面上項(xiàng)目, 31671393、“線粒體外膜蛋白Sam50在線粒體動(dòng)力學(xué)及線粒體自噬調(diào)控中的作用及分子機(jī)制研究”、2017/01-2020/12，62萬(wàn)元、已結(jié)題、主持

代表性研究論文

1. Jun Dong^#, Li Chen^#, Fei Ye^#, Junhui Tang, Bing Liu, Jiacheng Lin, Pang-Hu Zhou, Bin Lu, Min Wu, Jia-Hong Lu, Jing-Jing He, Simone Engelender, Qingtao Meng,Zhiyin Song*, He He*. (2024). Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.Nature Communications.15(1):168

2. Tianshu Hao^#, Jianglong Yu^#, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, Simone Engelender, He He*,Zhiyin Song*(2023)Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion.Nature Communications.14(1):4105

3. Li Chen^#, Jun Dong^#, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu, Chaojun Yan, Yong Chen, He He, Qingtao Meng*,Zhiyin Song*. (2022)Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.Hepatology.76(5):1389-1408

4. Siyang Liao; Li Chen;Zhiyin Song*; He He*. (2022) The fate of damaged mitochondrial DNA in the cell,Biochimica et Biophysica Acta - Molecular Cell Research,1869(5): 119233

5. Li Shu^#, Chao Hu^#, Meng Xu, Jianglong Yu, He He, Jie Lin, Hongying Sha, Bin Lu, Simone Engelende, Minxin Guan,Zhiyin Song*. (2021) ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.The EMBO Journal. 40(8):e106283

6.Zhida Wu^#, Meiling Zuo^#, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu,Zhiyin Song*. (2021) OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.EMBO Reports.22(1):e50827

7. Junhui Tang^#, Kuan Zhang^#, Jun Dong, Chaojun Yan, Chao Hu, Hongchao Ji, Liangyi Chen, Shi Chen, Huabin Zhao,Zhiyin Song*. (2020)Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.Cell Death and Differentiation.27(1):146-160

8.Chaojun Yan, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry,Zhiyin Song*(2020)PHB2(prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.Autophagy. 16(3):419-434

9. Chao Hu^#, Li Shu^#, Xiaoshuai Huang, Jianglong Yu, liuju Li, Longlong Gong, Meigui Yang, Zhida Wu, Zhi Gao, Yungang Zhao, Liangyi Chen*, andZhiyin Song*(2020) OPA1 and MICOS Regulate Mitochondrial Crista Dynamics and Formation.Cell Death & Disease. 11(10):940

10. Chaojun Yan, Xiaoying Duanmu, Ling Zeng, Bing Liu,Zhiyin Song*. (2019) Mitochondrial DNA: Distribution, Mutations, and Elimination.Cells. 8(4)

11.Fenglei Jian, Dan Chen, Li Chen, Chaojun Yan, Bin Lu, Yushan Zhu, Shi Chen, Anbing Shi, David C Chan,Zhiyin Song.*(2018)Sam50Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.Cell Reports.23(10), 2989-3005

12. Muhammad Riaz Khan, Shaoxun Xiang,Zhiyin Song*, Mian Wu*(2017)The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.The EMBO Journal.36(23):3483-3500

13.Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D,Song Z.*(2016)Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.Cell Death and Differentiation,23(3):380-92.

14. Kuan Zhang, Huihui Li,Zhiyin Song*(2014) Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.EMBO Reports, 15(5):576-85

15. Y Ruan, H Li, K Zhang, F Jian, J Tang,Z Song* (2013)Loss of Yme1L perturbates mitochondrial dynamics.Cell Death & Disease, 4:e896. doi: 10.1038/cddis.2013.414

16. Miao L^#,Song Z^#, Jin L, Zhu YM, Wen LP, Wu M. (2010) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation.Oncogene,29(5):711-722 (co-first author)

17Zhiyin Song, Mariam Ghochani, J Michael McCaffery, Terrence G Frey, David C Chan*. (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.Molecular Biology of the Cell,(15):3525-3532

18.Zhiyin Song,Hsiuchen Chen, Maja Fiket, Christiane Alexander, David C Chan. (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.Journal of Cell Biology.178(5):749-755

19.Zhiyin Song,Mian Wu*. (2005) Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation.Oncogene. 14; 24(16): 2723-2734

20.Zhiyin Song, Shixin Liu, He He, Naser Hoti, Yi Wang, Shanshan Feng, Mian Wu*. (2004) ASingle Amino Acid Change (Asp 53->Ala53) Converts Survivin from anti-apoptotic to pro-apoptotic.Molecular Biology of the Cell. 15(3):1287-1296

21.Zhiyin Song, Xuebiao Yao, Mian Wu. (2003) Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis.Journal of Biological Chemistry.278(25): 23130-23140