吳鵬飛，華中科技大學(xué)華中學(xué)者特聘教授、博士研究生導(dǎo)師，教育部“長江學(xué)者獎勵計劃”青年學(xué)者，湖北省醫(yī)學(xué)青年拔尖人才（第一層次），湖北省健康科普專家。中國藥理學(xué)會神經(jīng)精神藥理學(xué)會青年專業(yè)委員會副主任委員、武漢市藥理學(xué)會理事。聚焦于“應(yīng)激相關(guān)精神疾病的治療學(xué)新機(jī)制與新策略” 這一醫(yī)學(xué)前沿問題，開展轉(zhuǎn)化醫(yī)學(xué)&化學(xué)-神經(jīng)生物學(xué)導(dǎo)向的精神疾病發(fā)生機(jī)制和干預(yù)靶點(diǎn)研究，為抑郁癥、焦慮癥、創(chuàng)傷后應(yīng)激障礙、雙相情感障礙等精神障礙提供治療學(xué)新思路。主持國家自然科學(xué)基金4項(xiàng)，以通訊或第一作者（含共同）在Nature Metabolism、Redox Biology、Molecular Psychiatry、Brain, Behavior and Immunity、Biological Psychiatry、Aging Cell等國際知名期刊上發(fā)表論文34篇，他引1600余次。入選教育部基礎(chǔ)醫(yī)學(xué)“101計劃”核心教材編委。獲中國藥理學(xué)會施維雅青年藥理學(xué)家獎、高等學(xué)校科學(xué)研究優(yōu)秀成果一等獎（6/7）、華夏醫(yī)學(xué)科技進(jìn)步獎（4/11）、湖北省自然科學(xué)優(yōu)秀論文獎一等獎、華中科技大學(xué)教師教學(xué)競賽一等獎、湖北省/武漢藥理學(xué)會教學(xué)競賽一等獎等獎勵。兩次在世界藥理學(xué)大會 (WCP2018，日本京都；WCP2023，英國格拉斯哥) 上做報告。指導(dǎo)學(xué)生獲第一屆全國人工智能+大學(xué)生創(chuàng)新創(chuàng)業(yè)大賽一等獎（優(yōu)秀指導(dǎo)老師）等。被評為華中科技大學(xué)十佳青年教工、華中科技大學(xué)優(yōu)秀共產(chǎn)黨員、華中科技大學(xué)優(yōu)秀教師班主任等。

聯(lián)系方式：wupengfeipharm@foxmail.com

主要研究項(xiàng)目：

1 No. 82373858 蛋氨酸氧化酶MICAL1介導(dǎo)的細(xì)胞骨架動力學(xué)異常在創(chuàng)傷后應(yīng)激障礙中的作用及機(jī)制，國家自然科學(xué)基金面上項(xiàng)目，主持

2 No. 82073834 高爾基體酰基轉(zhuǎn)移酶GODZ介導(dǎo)的GluN2B-NMDA受體脂分揀信號異常在抑郁癥發(fā)生中的作用及其藥物干預(yù)，國家自然科學(xué)基金面上項(xiàng)目，主持

3 No.81773712 轉(zhuǎn)運(yùn)蛋白SVCT2依賴的維生素C穩(wěn)態(tài)調(diào)控機(jī)制異常在抑郁癥發(fā)病中的作用及藥物干預(yù)研究，國家自然科學(xué)基金面上項(xiàng)目，主持

4 No.81302754 蛋氨酸亞砜還原酶A負(fù)性調(diào)控ROS/MAPKs/NF-kB信號通路在小膠質(zhì)細(xì)胞炎性活化中的作用及機(jī)制，國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目，主持

5 2019 湖北省高校省級教學(xué)改革研究項(xiàng)目：德育目標(biāo)導(dǎo)向的基礎(chǔ)醫(yī)學(xué)課程思政教育資源共享平臺的建設(shè)和應(yīng)用，主持

6 華中科技大學(xué)創(chuàng)新研究基金重點(diǎn)項(xiàng)目《基于蛋白質(zhì)去棕櫚酰化機(jī)制的AMPA受體增強(qiáng)劑開發(fā)及其抗抑郁效應(yīng)研究》，主持

7 華中科技大學(xué)創(chuàng)新研究基金（轉(zhuǎn)化醫(yī)學(xué)專項(xiàng)）《氧化應(yīng)激生物標(biāo)記物蛋白質(zhì)蛋氨酸亞砜的快速檢測試劑盒》，主持

代表性學(xué)術(shù)論文：

Cun-Dong Huang, Yu Shi, Fang Wang*(通訊作者), Peng-Fei Wu* (通訊作者), Jian-Guo Chen*(通訊作者). Methionine oxidation of actin cytoskeleton attenuates traumatic memory retention via reactivating dendritic spine morphogenesis. Redox Biol. 2024:77:103391.

Xia-Ping Yao, Jian Ye, Ting Feng, Feng-Chao Jiang, Ping Zhou, Fang Wang*(通訊作者), Jian-Guo Chen*(通訊作者), Peng-Fei Wu*(通訊作者). Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals. Brain Behav Immun. 2023; 108:204-220.  

Pei Wang, Peng-Fei Wu^# (共同第一作者), Hua-Jie Wang, Fang Liao, Fang Wang* (通訊作者), Jian-Guo Chen* (通訊作者). Gut microbiome-derived ammonia modulates stress vulnerability in the host. Nature Metabolism 2023; 5(11):1986-2001. (相關(guān)專題評述：Keep calm with ammonia-producing microbiota. Nat Rev Microbiol. 2024;22(1):2. )

Jia-Jing Lu, Peng-Fei Wu^# (共同第一作者), Jin-Gang He, Yu-Ke Li, Li-Hong Long, Xia-Ping Yao, Jia-Hao Yang, Hong-Sheng Chen, Xiangnan Zhang, Zhuang-Li Hu, Zhong Chen, Fang Wang* (通訊作者) and Jian-Guo Chen*(通訊作者). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α. Molecular Psychiatry 2023 Mar 13. doi: 10.1038/s41380-023-02008-z.

Qian-Qian Han, Peng-Fei Wu^#* (共同第一/通訊作者), Yi-Heng Li, Yu Cao, Jian-Guo Chen*(通訊作者), Fang Wang*(通訊作者). SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene. Redox Biology 2022; 58:102543.  

Peng-Fei Wu^#, Xin-Lei Guan^#, Fang Wang, Jian-Guo Chen*. N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis. Acta Pharmacologica Sinica 2022; 43(2):260-272.

Pei Wang, Fang Wang, Lan Ni, Peng-Fei Wu*(通訊作者), Jian-Guo Chen*(通訊作者). Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder, Acta Pharm Sin B 2021, 11(3):599-608.

Peng-Fei Wu^#, Qian-Qian Han^#, Fu-Feng Chen, Tian-Tian Shen, Yi-Heng Li, Yu Cao, Jian-Guo Chen, Fang Wang*. Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions. Neurobiology of Stress 2021, 15:100390.

Xu JF, Lu JJ, Cao Y, Wang W, Li HH, Chen JG, Wang F(通訊作者), Wu PF (通訊作者). Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression. Neuropharmacology. 2020; 176:108235.

Luo H, Wu PF^# (共同第一作者), Cao Y, Jin M, Shen TT, Wang J, Huang JG, Han QQ, He JG, Deng SL, Ni L, Hu ZL, Long LH, Wang F, Chen JG. Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1. Biological Psychiatry. 2020; 88(5):415-425. (相關(guān)專題評述：Bringing in the ACE(i): Angiotensin-Converting Enzyme Inhibitors as Antidepressants. Biol Psychiatry. 2020；Angiotensin-converting enzyme inhibitors produce rapid antidepressant effects in a bradykinin-dependent manner. Folia Pharmacologica Japonica 2020 )

Shen ZC, Wu PF^# (共同第一作者),Wang F, Deng Q, Nie TL, Zhang SQ, Zheng HL, Liu WH, Lu JJ, Gao SQ, Yao XP, Long LH, Hu ZL, Chen JG. Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine. Biological Psychiatry 2019; 85(3):202-213.

Xia ZX, Shen ZC, Zhang SQ, Wang J, Nie TL, Deng Q, Chen JG, Wang F*(通訊作者), Wu PF*(通訊作者). De-palmitoylation by N-(tert-Butyl) hydroxylamine inhibits AMPAR-mediated synaptic transmission via affecting receptor distribution in postsynaptic densities. CNS Neurosci Ther 2019; 25(2):187-199.

Luo H, Wu PF^# (共同第一作者), Han QQ, Cao Y, Deng SL, Wang J, Deng Q, Wang F, Chen JG. Reactive Sulfur Species Emerge as Gliotransmitters to Support Memory via Sulfuration-Dependent Gating of NR2A-Containing N-Methyl-d-Aspartate Subtype Glutamate Receptor Function. Antioxid Redox Signal 2019; 30(16):1880-1899.

Li YL, Wu PF^# (共同第一作者), Chen JG, Wang S, Han QQ, Li D, Wang W, Guan XL, Li D, Long LH, Huang JG, Wang F. Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity via Increasing d-Serine Availability. Antioxid Redox Signal 2017; 27(7):398-414.（封面文章）

Guan XL, Wu PF^# (共同第一作者), Wang S, Zhang JJ, Shen ZC, Luo H, Chen H, Long LH, Chen JG, Wang F. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism. Aging Cell. 2017; 16(2): 226-236.

Fan H, Wu PF^# (共同第一作者), Zhang L, Hu ZL, Wang W, Guan XL, Luo H, Ni M, Yang JW, Li MX, Chen JG*, Wang F*. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal. 2015; 22(10):832-47.

Li YL, Zhou J, Zhang H, Luo Y, Long LH, Hu ZL, Chen JG, Wang F, Wu PF (通訊作者). Hydrogen Sulfide Promotes Surface Insertion of Hippocampal AMPA Receptor GluR1 Subunit via Phosphorylating at Serine-831/Serine-845 Sites Through a Sulfhydration-Dependent Mechanism. CNS Neurosci Ther. 2016, 22(9):789-98.

Wang X, Cao H, Guan XL, Long LH, Hu ZL, Ni L, Wang F, Chen JG, Wu PF (通訊作者). Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism. Toxicol Lett.2016, 258:237-48.

Han J, Zhang H, Wang S, Zhou J, Luo Y, Long LH, Hu ZL, Wang F, Chen JG, Wu PF (通訊作者). Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation. Neurochem Res. 2016, 41(11):2890-2903.

Ma J, Long LH, Hu ZL, Zhang H, Han J, Ni L, Wang F, Chen JG, Wu PF(通訊作者). Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain Res. 2015; 1615:71-9.

Wu PF, Xie N, Zhang JJ, Guan XL, Zhou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG*. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem. 2013; 24(6):1070-7.

Wu PF, Zhang Z, Guan XL, Li YL, Zeng JH, Zhang JJ, Long LH, Hu ZL, Wang F, Chen JG. A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A. Enzyme Microb Technol. 2013; 53(6-7):391-7.

Wu PF, Long LH, Zeng JH, Guan XL, Zhou J, Jin Y, Ni L, Wang F, Chen JG, Xie N. Protection of L-methionine against H?O?-induced oxidative damage in mitochondria. Food Chem Toxicol. 2012, 50(8):2729-35.

Lu HF, Wu PF^# (共同第一作者), Yang YJ, Xiao W, Fan J, Liu J, Li YL, Luo Y, Hu ZL, Jin Y, Wang F*, Chen JG*. Interactions between N-ethylmaleimide- sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. J Neurosci. 2014; 34(10):3493-508.

Yang YJ, Wu PF^# (共同第一作者), Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F*, Chen JG*. Reversal of aging- associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. Aging Cell. 2010; 9(5):709-21.

發(fā)明專利：

1 紅藻氨酸和/或紅藻氨酸鹽在制備抗焦慮藥物中的應(yīng)用，申請?zhí)枺?/span>2024114846279，排名第二

2  2-溴棕櫚酸滴鼻劑在制備抗抑郁藥物中的應(yīng)用，申請?zhí)枺?/span>2024114847036，排名第二

3  一種用于防治創(chuàng)傷后應(yīng)激綜合征的藥物和功能性食品；授權(quán)專利號：ZL 2017 1 1235555.4，排名第二

4  一種快速消除口臭的生物技術(shù)口氣清新劑及其醫(yī)藥用途；授權(quán)專利號：ZL 2015 1 0870376.2，排名第二；

5一種蛋氨酸亞砜還原酶活性的檢測方法及藥物篩選試劑盒；授權(quán)專利號：ZL 2009 1 0273177.8，排名第二；

6 重組Trx-TAT-hMsrA融合蛋白及其在神經(jīng)細(xì)胞保護(hù)方面的應(yīng)用；授權(quán)專利號：ZL 2010 1 0197729.4，排名第三（“獨(dú)占許可”形式轉(zhuǎn)讓）；

7 含巰基他克林衍生物及其制備方法和應(yīng)用；授權(quán)專利號：ZL 2011 1 0216334. 9，排名第六；

8 氨基噻唑衍生物及制備方法和醫(yī)藥用途；授權(quán)專利號：ZL 2011 1 0216344.2，排名第七